MEDICA 16
Biological Activity
Free fatty acid 1 (FFA1/GPR40) receptor agonist; exhibits selectivity for FFA1 (GPR40) over GPR120. Also inhibits ATP citrate lyase; reduces intracellular triacylglycerol levels in muscle, inhibits lipogenesis and increases insulin sensitivity in rodents in vivo.
Technical Data
| M. Wt | 342.51 |
| Formula | C20H38O4 |
| Storage | Store at -20°C |
| CAS Number | 87272-20-6 |
| PubChem ID | 121871 |
| InChI Key | HYSMCRNFENOHJH-UHFFFAOYSA-N |
| Smiles | CC(CC(O)=O)(C)CCCCCCCCCCC(C)(C)CC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.25 | 100 | |
| ethanol | 34.25 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 342.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.92 mL | 14.6 mL | 29.2 mL |
| 5 mM | 0.58 mL | 2.92 mL | 5.84 mL |
| 10 mM | 0.29 mL | 1.46 mL | 2.92 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
Molarity Calculator
Reconstitution Calculator
Dilution Calculator
Product Datasheets
References
References are publications that support the biological activity of the product.
Hara et al (2009) Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch.Pharmacol. 380 247 PMID: 19471906
Atkinson et al (2002) MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR:LA-cp rats. Diabetes 51 1548 PMID: 11978655
If you know of a relevant reference for MEDICA 16, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: MEDICA 16, MEDICA 16 supplier, MEDICA16, free, fatty, acid, receptors, 1, FFA1, FFAR1, GPR40, agonists, ATP, citrate, lyases, inhibitors, inhibits, lipogenesis, insulin, sensitivity, triacylglyerol, synthases, transferases, ACLY, Free, Fatty, Acid, Receptors, Citrate, Lyase, 4615, Tocris Bioscience
Citations for MEDICA 16
Citations are publications that use Tocris products.
Currently there are no citations for MEDICA 16. Do you know of a great paper that uses MEDICA 16 from Tocris? Please let us know.
Reviews for MEDICA 16
There are currently no reviews for this product. Be the first to review MEDICA 16 and earn rewards!
Have you used MEDICA 16?
Submit a review and receive an Amazon gift card.
$10US/$10CAN/€7/£6 gift card for a review without an image
$25US/$25CAN/€18/£15 gift card for a review with an image
*Offer only valid in the USA / Canada, UK and Europe
Submit a ReviewLiterature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GPCR Product Listing
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Secretin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
