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Cat.No. 4615 - MEDICA 16 | C20H38O4 | CAS No. 87272-20-6
Description: FFA1 (GPR40) agonist; also inhibits ATP citrate lyase
Chemical Name: 3,3,14,14-Tetramethylhexadecanedioic acid
Literature (1)

Biological Activity for MEDICA 16

MEDICA 16 is a free fatty acid 1 (FFA1/GPR40) receptor agonist; exhibits selectivity for FFA1 (GPR40) over GPR120. Also inhibits ATP citrate lyase; reduces intracellular triacylglycerol levels in muscle, inhibits lipogenesis and increases insulin sensitivity in rodents in vivo.

Technical Data for MEDICA 16

M. Wt 342.51
Formula C20H38O4
Storage Store at -20°C
CAS Number 87272-20-6
PubChem ID 121871

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for MEDICA 16

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 34.25 100
ethanol 34.25 100

Preparing Stock Solutions for MEDICA 16

The following data is based on the product molecular weight 342.51. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.92 mL 14.6 mL 29.2 mL
5 mM 0.58 mL 2.92 mL 5.84 mL
10 mM 0.29 mL 1.46 mL 2.92 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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References for MEDICA 16

References are publications that support the biological activity of the product.

Hara et al (2009) Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch.Pharmacol. 380 247 PMID: 19471906

Atkinson et al (2002) MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in Ins-resistant JCR:LA-cp rats. Diabetes 51 1548 PMID: 11978655

If you know of a relevant reference for MEDICA 16, please let us know.

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Keywords: MEDICA 16, MEDICA 16 supplier, MEDICA16, free, fatty, acid, receptors, 1, FFA1, FFAR1, GPR40, agonists, ATP, citrate, lyases, inhibitors, inhibits, lipogenesis, insulin, sensitivity, triacylglyerol, synthases, transferases, ACLY, Free, Fatty, Acid, Receptors, Citrate, Lyase, 4615, Tocris Bioscience

Citations for MEDICA 16

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