MEDICA 16

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Cat.No. 4615 - MEDICA 16 | C20H38O4 | CAS No. 87272-20-6
Description: FFA1 (GPR40) agonist; also inhibits ATP citrate lyase
Chemical Name: 3,3,14,14-Tetramethylhexadecanedioic acid
Datasheet
Citations
Literature

Biological Activity

Free fatty acid 1 (FFA1/GPR40) receptor agonist; exhibits selectivity for FFA1 (GPR40) over GPR120. Also inhibits ATP citrate lyase; reduces intracellular triacylglycerol levels in muscle, inhibits lipogenesis and increases insulin sensitivity in rodents in vivo.

Technical Data

M. Wt 342.51
Formula C20H38O4
Storage Store at -20°C
CAS Number 87272-20-6
PubChem ID 121871
InChI Key HYSMCRNFENOHJH-UHFFFAOYSA-N
Smiles CC(CC(O)=O)(C)CCCCCCCCCCC(C)(C)CC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.25 100
ethanol 34.25 100

Preparing Stock Solutions

The following data is based on the product molecular weight 342.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.92 mL 14.6 mL 29.2 mL
5 mM 0.58 mL 2.92 mL 5.84 mL
10 mM 0.29 mL 1.46 mL 2.92 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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References

References are publications that support the products' biological activity.

Hara et al (2009) Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch.Pharmacol. 380 247 PMID: 19471906

Atkinson et al (2002) MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR:LA-cp rats. Diabetes 51 1548 PMID: 11978655


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Citations for MEDICA 16

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