LY 78335

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Cat.No. 4060 - LY 78335 | C8H9Cl2N.HCl | CAS No. 39959-66-5
Description: Phenylethanolamine-N-methyltransferase inhibitor
Chemical Name: 2,3-Dichloro-α-methylbenzylamine hydrochloride
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity

High affinity inhibitor of phenylethanolamine-N-methyltransferase (PNMT) (Ki = 0.09 μM in vitro). Suppresses the release of growth hormone in an in vivo rat model.

Technical Data

M. Wt 226.53
Formula C8H9Cl2N.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 39959-66-5
PubChem ID 11957540
Smiles NC(C)C1=C(Cl)C(Cl)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 22.65 100 with gentle warming
DMSO 22.65 100 with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 226.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.41 mL 22.07 mL 44.14 mL
5 mM 0.88 mL 4.41 mL 8.83 mL
10 mM 0.44 mL 2.21 mL 4.41 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

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References are publications that support the biological activity of the product.

Fuller et al (1973) Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 2. In vitro and in vivo studies with 2,3-dichloro-α-methylbenzylamine. J.Med.Chem. 16 106 PMID: 4683104

Terry et al (1982) Regulation of episodic GH secretion by the central epinephrine system. J.Clin.Invest. 69 104 PMID: 7054231

Grunewald et al (1988) Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase. J.Med.Chem. 31 824 PMID: 3351861

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Keywords: LY 78335, LY 78335 supplier, LY78335, phenylethanolamine-N-methyltransferase, PNMT, high, affinity, inhibitors, inhibits, methyltransferases, Other, Transferases, 4060, Tocris Bioscience

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