Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewLY 78335
Description: Phenylethanolamine-N-methyltransferase inhibitor
Chemical Name: 2,3-Dichloro-α-methylbenzylamine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity
High affinity inhibitor of phenylethanolamine-N-methyltransferase (PNMT) (Ki = 0.09 μM in vitro). Suppresses the release of growth hormone in an in vivo rat model.
Technical Data
| M. Wt | 226.53 |
| Formula | C8H9Cl2N.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 39959-66-5 |
| PubChem ID | 11957540 |
| InChI Key | FQTXPVLCCDQRHY-UHFFFAOYSA-N |
| Smiles | NC(C)C1=C(Cl)C(Cl)=CC=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 22.65 | 100 with gentle warming | |
| DMSO | 22.65 | 100 with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 226.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.41 mL | 22.07 mL | 44.14 mL |
| 5 mM | 0.88 mL | 4.41 mL | 8.83 mL |
| 10 mM | 0.44 mL | 2.21 mL | 4.41 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.88 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets
References
References are publications that support the biological activity of the product.
Fuller et al (1973) Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 2. In vitro and in vivo studies with 2,3-dichloro-α-methylbenzylamine. J.Med.Chem. 16 106 PMID: 4683104
Terry et al (1982) Regulation of episodic GH secretion by the central epinephrine system. J.Clin.Invest. 69 104 PMID: 7054231
Grunewald et al (1988) Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase. J.Med.Chem. 31 824 PMID: 3351861
If you know of a relevant reference for LY 78335, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: LY 78335, LY 78335 supplier, LY78335, phenylethanolamine-N-methyltransferase, PNMT, high, affinity, inhibitors, inhibits, methyltransferases, Other, Transferases, 4060, Tocris Bioscience
Citations for LY 78335
Citations are publications that use Tocris products.
Currently there are no citations for LY 78335. Do you know of a great paper that uses LY 78335 from Tocris? Please let us know.
Reviews for LY 78335
There are currently no reviews for this product. Be the first to review LY 78335 and earn rewards!
Have you used LY 78335?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
New Product Guide [Spring/Summer 2019]New
Our new product guide highlights over 215 new products added to the Tocris Bioscience range during the first half of 2019.
- 7-TM Receptors
- Enzymes
- Enzyme-Linked Receptors
- Ion Channels
- Nuclear Receptors
- Transporters
- Chemogenetics
- Epigenetics
- Fluorescent Imaging
- PROTACs
- Signal Transduction
- Stem Cells