LY 78335

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Cat.No. 4060 - LY 78335 | C8H9Cl2N.HCl | CAS No. 39959-66-5
Description: Phenylethanolamine-N-methyltransferase inhibitor
Chemical Name: 2,3-Dichloro-α-methylbenzylamine hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

High affinity inhibitor of phenylethanolamine-N-methyltransferase (PNMT) (Ki = 0.09 μM in vitro). Suppresses the release of growth hormone in an in vivo rat model.

Technical Data

M. Wt 226.53
Formula C8H9Cl2N.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 39959-66-5
PubChem ID 11957540
InChI Key FQTXPVLCCDQRHY-UHFFFAOYSA-N
Smiles NC(C)C1=C(Cl)C(Cl)=CC=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 22.65 100mM with gentle warming
water 22.65 100mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 226.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.41 mL 22.07 mL 44.14 mL
5 mM 0.88 mL 4.41 mL 8.83 mL
10 mM 0.44 mL 2.21 mL 4.41 mL
50 mM 0.09 mL 0.44 mL 0.88 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Fuller et al (1973) Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 2. In vitro and in vivo studies with 2,3-dichloro-α-methylbenzylamine. J.Med.Chem. 16 106 PMID: 4683104

Terry et al (1982) Regulation of episodic growth hormone secretion by the central epinephrine system. J.Clin.Invest. 69 104 PMID: 7054231

Grunewald et al (1988) Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase. J.Med.Chem. 31 824 PMID: 3351861


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Keywords: LY 78335, supplier, LY78335, phenylethanolamine-N-methyltransferase, PNMT, high, affinity, inhibitors, inhibits, methyltransferases, Other, Transferases, Other, Transferases, Tocris Bioscience

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