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Description: Phenylethanolamine-N-methyltransferase inhibitor
Chemical Name: 2,3-Dichloro-α-methylbenzylamine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity
High affinity inhibitor of phenylethanolamine-N-methyltransferase (PNMT) (Ki = 0.09 μM in vitro). Suppresses the release of growth hormone in an in vivo rat model.
Technical Data
| M. Wt | 226.53 |
| Formula | C8H9Cl2N.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 39959-66-5 |
| PubChem ID | 11957540 |
| InChI Key | FQTXPVLCCDQRHY-UHFFFAOYSA-N |
| Smiles | NC(C)C1=C(Cl)C(Cl)=CC=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 22.65 | 100 with gentle warming | |
| DMSO | 22.65 | 100 with gentle warming |
Preparing Stock Solutions
The following data is based on the product molecular weight 226.53. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.41 mL | 22.07 mL | 44.14 mL |
| 5 mM | 0.88 mL | 4.41 mL | 8.83 mL |
| 10 mM | 0.44 mL | 2.21 mL | 4.41 mL |
| 50 mM | 0.09 mL | 0.44 mL | 0.88 mL |
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References
References are publications that support the biological activity of the product.
Fuller et al (1973) Inhibition of phenylethanolamine N-methyltransferase by benzylamines. 2. In vitro and in vivo studies with 2,3-dichloro-α-methylbenzylamine. J.Med.Chem. 16 106 PMID: 4683104
Terry et al (1982) Regulation of episodic GH secretion by the central epinephrine system. J.Clin.Invest. 69 104 PMID: 7054231
Grunewald et al (1988) Synthesis and evaluation of 3-substituted analogues of 1,2,3,4-tetrahydroisoquinoline as inhibitors of phenylethanolamine N-methyltransferase. J.Med.Chem. 31 824 PMID: 3351861
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Keywords: LY 78335, LY 78335 supplier, LY78335, phenylethanolamine-N-methyltransferase, PNMT, high, affinity, inhibitors, inhibits, methyltransferases, Other, Transferases, 4060, Tocris Bioscience
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