LY 2365109 hydrochloride

Pricing Availability   Qty
Description: Potent and selective GlyT1 inhibitor
Chemical Name: N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycine hydrochloride
Purity: ≥98% (HPLC)

Biological Activity for LY 2365109 hydrochloride

LY 2365109 hydrochloride is a potent and selective glycine transporter 1 (GlyT1) inhibitor (IC50 values are 15.8 and > 30 000 nM at GlyT1 and GlyT2 respectively). Induces a dose-dependent elevation in CSF levels of glycine, and enhances acetylcholine and dopamine release in the striatum and prefrontal cortex respectively. Produces profound locomotor and respiratory impairments at higher doses.

Technical Data for LY 2365109 hydrochloride

M. Wt 421.91
Formula C22H27NO5.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 1779796-27-8
PubChem ID 56972229
Smiles CC(C)(C)C1=C(OCCN(C)CC(O)=O)C=CC(C2=CC(OCO3)=C3C=C2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for LY 2365109 hydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 42.19 100
ethanol 21.1 50

Preparing Stock Solutions for LY 2365109 hydrochloride

The following data is based on the product molecular weight 421.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.85 mL 23.7 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
10 mM 0.24 mL 1.19 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

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Product Datasheets for LY 2365109 hydrochloride

Certificate of Analysis / Product Datasheet
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References for LY 2365109 hydrochloride

References are publications that support the biological activity of the product.

Perry et al (2008) Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs cortical brain areas. Neuropharmacology 55 743 PMID: 18602930

If you know of a relevant reference for LY 2365109 hydrochloride, please let us know.

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Citations for LY 2365109 hydrochloride

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