LY 2365109 hydrochloride

Pricing Availability Delivery Time Qty
Cat.No. 3397 - LY 2365109 hydrochloride | C22H27NO5.HCl | CAS No. 868265-28-5
Description: Potent and selective GlyT1 inhibitor
Chemical Name: N-[2-[4-(1,3-Benzodioxol-5-yl)-2-(1,1-dimethylethyl)phenoxy]ethyl]-N-methylglycine hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective glycine transporter 1 (GlyT1) inhibitor (IC50 values are 15.8 and > 30 000 nM at GlyT1 and GlyT2 respectively). Induces a dose-dependent elevation in CSF levels of glycine, and enhances acetylcholine and dopamine release in the striatum and prefrontal cortex respectively. Produces profound locomotor and respiratory impairments at higher doses.

Compound Libraries

LY 2365109 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 421.91
Formula C22H27NO5.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 868265-28-5
PubChem ID 56972229
InChI Key ZQVOAGQZHDAFRM-UHFFFAOYSA-N
Smiles CC(C)(C)C1=C(OCCN(C)CC(O)=O)C=CC(C2=CC(OCO3)=C3C=C2)=C1.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 42.19 100
ethanol 21.1 50

Preparing Stock Solutions

The following data is based on the product molecular weight 421.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.37 mL 11.85 mL 23.7 mL
5 mM 0.47 mL 2.37 mL 4.74 mL
10 mM 0.24 mL 1.19 mL 2.37 mL
50 mM 0.05 mL 0.24 mL 0.47 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Perry et al (2008) Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs cortical brain areas. Neuropharmacology 55 743 PMID: 18602930


If you know of a relevant reference for LY 2365109 hydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Glycine Transporter Inhibitors

Keywords: LY 2365109 hydrochloride, supplier, Potent, selective, GlyT1, inhibitors, inhibits, Glycine, Transporters, Monoamine, Neurotransmitter, LY2365109, hydrochloride, Glycine, Transporters, Tocris Bioscience

Citations for LY 2365109 hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for LY 2365109 hydrochloride. Do you know of a great paper that uses LY 2365109 hydrochloride from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

Schizophrenia

Schizophrenia Poster

Schizophrenia is a debilitating psychiatric disorder that affects 1% of the worldwide population. This poster describes the neurobiology of Schizophrenia, as well as highlighting the genetic and environmental factors that play a fundamental role in the etiology of the disease. The current and emerging drug targets are also discussed.

Pathways for LY 2365109 hydrochloride

Protocols

TODO: Add Protocols