You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
LY 2365109 hydrochloride
Biological Activity for LY 2365109 hydrochloride
LY 2365109 hydrochloride is a potent and selective glycine transporter 1 (GlyT1) inhibitor (IC50 values are 15.8 and > 30 000 nM at GlyT1 and GlyT2 respectively). Induces a dose-dependent elevation in CSF levels of glycine, and enhances acetylcholine and dopamine release in the striatum and prefrontal cortex respectively. Produces profound locomotor and respiratory impairments at higher doses.
Technical Data for LY 2365109 hydrochloride
|Storage||Desiccate at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LY 2365109 hydrochloride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for LY 2365109 hydrochloride
The following data is based on the product molecular weight 421.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.37 mL||11.85 mL||23.7 mL|
|5 mM||0.47 mL||2.37 mL||4.74 mL|
|10 mM||0.24 mL||1.19 mL||2.37 mL|
|50 mM||0.05 mL||0.24 mL||0.47 mL|
Product Datasheets for LY 2365109 hydrochloride
References for LY 2365109 hydrochloride
References are publications that support the biological activity of the product.
Perry et al (2008) Neurochemical and behavioral profiling of the selective GlyT1 inhibitors ALX5407 and LY2365109 indicate a preferential action in caudal vs cortical brain areas. Neuropharmacology 55 743 PMID: 18602930
If you know of a relevant reference for LY 2365109 hydrochloride, please let us know.
View Related Products by Product Action
Keywords: LY 2365109 hydrochloride, LY 2365109 hydrochloride supplier, Potent, selective, GlyT1, inhibitors, inhibits, Glycine, Transporters, Monoamine, Neurotransmitter, LY2365109, hydrochloride, 3397, Tocris Bioscience
Citations for LY 2365109 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for LY 2365109 hydrochloride. Do you know of a great paper that uses LY 2365109 hydrochloride from Tocris? Please let us know.
Reviews for LY 2365109 hydrochloride
There are currently no reviews for this product. Be the first to review LY 2365109 hydrochloride and earn rewards!
Have you used LY 2365109 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image