LY 233053

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Cat.No. 1521 - LY 233053 | C8H13N5O2 | CAS No. 125546-04-5
Description: Competitive NMDA receptor antagonist
Chemical Name: (2R*,4S*)-4-(1H-Tetrazol-5-ylmethyl)-2-piperidinecarboxylic acid
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Competitive NMDA receptor antagonist (IC50 = 7 nM) that displays no affinity for AMPA or kainate receptors at a concentration of 10 μM. Inhibits NMDA-induced neuronal degeneration and protects from NMDA-induced convulsions in neonatal rats.

Licensing Information

Sold with the permission of Eli Lilly and Company

Technical Data

M. Wt 211.22
Formula C8H13N5O2
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 125546-04-5
PubChem ID 90479799
InChI Key RTVQJOXSBRCZBN-JUKSSJACSA-N
Smiles O=[C@@]([C@@H]1C[C@H](CC2=NN=NN2)CCN1)O.O=C([C@H]3C[C@@H](CC4=NN=NN4)CCN3)O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 21.12 100
water 21.12 100

Preparing Stock Solutions

The following data is based on the product molecular weight 211.22. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.73 mL 23.67 mL 47.34 mL
5 mM 0.95 mL 4.73 mL 9.47 mL
10 mM 0.47 mL 2.37 mL 4.73 mL
50 mM 0.09 mL 0.47 mL 0.95 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Schoepp et al (1990) Pharmacological characterization of LY233053: a structurally novel tetrazole-substituted competitive N-methyl-D-aspartic acid antagonist with a short duration of action. J.Pharmacol.Exp.Ther. 255 1301 PMID: 2148188

Madden et al (1992) Efficacy of LY233053, a competitive glutamate antagonist, in experimental central nervous system ischemia. J.Neurosurg. 76 106 PMID: 1727148

Madden et al (1993) Delayed therapy of experimental ischemia with competitive N-methyl-D-aspartate antagonists in rabbits. Stroke 24 1068 PMID: 8322381


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Keywords: LY 233053, supplier, Competitive, NMDA, receptor, antagonists, Glutamate, Receptors, N-Methyl-D-Aspartate, iGlur, Ionotropic, LY233053, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience

Citations for LY 233053

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