Selective, orally active leukotriene D4 (LTD4) antagonist; inhibits binding of [3H]-LTD4 to guinea pig lung membranes (Ki = 0.63 μM). Acts as an agonist at peroxisome proliferator-activated receptors (PPARs).
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The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Fleisch et al (1985) LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5-yl) butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist. J.Pharmacol.Exp.Ther. 233 148 PMID: 3981452
Aharony et al (1987) Inhibition of 3H-leukotriene D4 binding to guinea pig lung receptors by the novel leukotriene antagonist ICI 198,615. J.Pharmacol.Exp.Ther. 243 921 PMID: 2826761
Cannon and Eacho (1991) Interaction of LY171883 and other peroxisome proliferators with fatty-acid-binding protein isolated from rat liver. Biochem.J. 280 387 PMID: 1747111
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Keywords: LY 171883, LY 171883 supplier, Selective, orally, active, LTD4, antagonists, CysLT1, Receptors, LY171883, Tomelukast, Leukotriene, and, Related, 2140, Tocris Bioscience
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