LY 171883

Discontinued Product

Unfortunately LY 171883 (Cat. No. 2140) has been withdrawn from sale for commercial reasons.
Cat.No. 2140 - LY 171883 | C16H22N4O3 | CAS No. 88107-10-2
Description: Selective, orally active LTD4 antagonist
Alternative Names: Tomelukast
Chemical Name: 1-[2-Hydroxy-3-propyl-4-[4-(1H-tetrazol-5-yl)butoxy]phenyl]ethanone
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective, orally active leukotriene D4 (LTD4) antagonist; inhibits binding of [3H]-LTD4 to guinea pig lung membranes (Ki = 0.63 μM).  Acts as an agonist at peroxisome proliferator-activated receptors (PPARs).

Technical Data

M. Wt 318.37
Formula C16H22N4O3
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 88107-10-2
Smiles OC1=C(CCC)C(OCCCCC2=NN=NN2)=CC=C1C(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 318.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.14 mL 15.7 mL 31.41 mL
5 mM 0.63 mL 3.14 mL 6.28 mL
10 mM 0.31 mL 1.57 mL 3.14 mL
50 mM 0.06 mL 0.31 mL 0.63 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Fleisch et al (1985) LY171883, 1-less than 2-hydroxy-3-propyl-4-less than 4-(1H-tetrazol-5-yl) butoxy greater than phenyl greater than ethanone, an orally active leukotriene D4 antagonist. J.Pharmacol.Exp.Ther. 233 148 PMID: 3981452

Aharony et al (1987) Inhibition of 3H-leukotriene D4 binding to guinea pig lung receptors by the novel leukotriene antagonist ICI 198,615. J.Pharmacol.Exp.Ther. 243 921 PMID: 2826761

Cannon and Eacho (1991) Interaction of LY171883 and other peroxisome proliferators with fatty-acid-binding protein isolated from rat liver. Biochem.J. 280 387 PMID: 1747111

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Keywords: LY 171883, supplier, Selective, orally, active, LTD4, antagonists, CysLT1, Receptors, LY171883, Tomelukast, Leukotriene, and, Related, Receptors, Tocris Bioscience

Citations for LY 171883

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