LOE 908 hydrochloride

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Cat.No. 2314 - LOE 908 hydrochloride | C41H48N2O9.HCl | CAS No. 143482-60-4
Description: Broad spectrum cation channel blocker; neuroprotective
Chemical Name: 3,4-Dihydro-6,7-dimethoxy-α-phenyl-N,N-bis[2-(2,3,4-trimethoxyphenyl)ethyl]-1-isoquinolineacetamide hydrochloride
Purity: ≥98% (HPLC)
Citations (2)

Biological Activity

Broad spectrum cation channel blocker. Inhibits several cation channels including store-operated calcium channels (SOCs), voltage-operated calcium channels (VOCs), non-selective cation channels (NSCCs), AMPA, NMDA, Na+ and K+ channels. Neuroprotective; reduces cortical infarct size and improves neurological outcome following middle cerebral artery occlusion.

Technical Data

M. Wt 749.29
Formula C41H48N2O9.HCl
Storage Desiccate at RT
Purity ≥98% (HPLC)
CAS Number 143482-60-4
PubChem ID 56846451

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 37.46 50
DMSO 74.93 100

Preparing Stock Solutions

The following data is based on the product molecular weight 749.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

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Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.33 mL 6.67 mL 13.35 mL
5 mM 0.27 mL 1.33 mL 2.67 mL
10 mM 0.13 mL 0.67 mL 1.33 mL
50 mM 0.03 mL 0.13 mL 0.27 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References are publications that support the biological activity of the product.

Christensen et al (2005) The broad-spectrum cation channel blocker pinokalant (LOE 908 MS) reduces brain infarct volume in rats: a temperature-controlled histological study. Basic Clin.Pharmacol.Toxicol. 96 316 PMID: 15755315

Krause et al (1998) LOE 908 blocks delayed rectifier type potassium channels in PC12 cells and cortical neurons in culture. Biochem.Biophys.Res.Comm. 244 659 PMID: 9535721

Tatlisumak et al (2000) Broad-spectrum cation channel inhibition by LOE 908 MS reduces infarct volume in vivo and postmortem in focal cerebral ischemia in the rat. J.Neurol.Sci. 178 107 PMID: 11018702

If you know of a relevant reference for LOE 908 hydrochloride, please let us know.

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2 Citations for LOE 908 hydrochloride

Citations are publications that use Tocris products. Selected citations for LOE 908 hydrochloride include:

Harper and Poole (2010) Protein kinase Ctheta negatively regulates store-independent Ca2+ entry and phosphatidylserine exposure downstream of glycoprotein VI in platelets. J Biol Chem 285 19865 PMID: 20388711

Varadarajan et al (2013) Endoplasmic reticulum membrane reorganization is regulated by ionic homeostasis. PLoS One 8 e56603 PMID: 23457590

Do you know of a great paper that uses LOE 908 hydrochloride from Tocris? Please let us know.

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