LDN 212320

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Cat.No. 5082 - LDN 212320 | C17H15N3S | CAS No. 894002-50-7
Description: Increases EAAT2 expression; neuroprotective
Chemical Name: 3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews (1)
Literature

Biological Activity

Increases expression of glutamate transporter EAAT2 in PA-EAAT2 cells. Displays neuroprotective activity in vivo. Shown to improve learning and memory, restore synaptic integrity and reduce amyloid plaque burden in APPSw/Ind mice.

Technical Data

M. Wt 293.39
Formula C17H15N3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 894002-50-7
PubChem ID 7207425
InChI Key DUUQLWDHNYFUPP-UHFFFAOYSA-N
Smiles CC1=CC=CC=C1CSC(N=N3)=CC=C3C2=NC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 5.87 20
DMSO 29.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 293.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.41 mL 17.04 mL 34.08 mL
5 mM 0.68 mL 3.41 mL 6.82 mL
10 mM 0.34 mL 1.7 mL 3.41 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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References

References are publications that support the biological activity of the product.

Lin et al (2012) Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases. Future Med Chem 4 1689 PMID: 22924507

Xing et al (2011) Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg.Med.Chem.Lett. 21 5774 PMID: 21875806

Lin et al (2013) : Mechanism of LDN-212320 induction of glutamate transporter EAAT2 expression . Society for Neuroscience (Abstract) 99

Takahashi et al (2013) A small molecule modulator of glutamate transporter EAAT2 ameliorates Alzheimer’s-like pathologies and memory deficits in APPSw/Ind mice. Society for Neuroscience (Abstract) 103


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Keywords: LDN 212320, LDN 212320 supplier, LDN212320, glutamate, transporters, EAAT2, Excitatory, Amino, Acid, Transporters, Monoamine, Neurotransmitters, Alzheimer's, disease, Glutamate, 5082, Tocris Bioscience

Citations for LDN 212320

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Reviews for LDN 212320

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Using LDN 212320 to increase GLT-1
By Crystal Wilkie on 01/12/2018
Species: Mouse

We used it to increase GLT-1 in mice brains. So far it has significantly increased GLT-1 after one injection.

It's hard to dissolve so we dissolved it in 100ul of DMSO first before adding the vehicle.

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