LDN 212320

Pricing Availability Delivery Time Qty
Cat.No. 5082 - LDN 212320 | C17H15N3S | CAS No. 894002-50-7
Description: Increases EAAT2 expression; neuroprotective
Chemical Name: 3-[[(2-Methylphenyl)methyl]thio]-6-(2-pyridinyl)-pyridazine
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Increases expression of glutamate transporter EAAT2 in PA-EAAT2 cells. Displays neuroprotective activity in vivo. Shown to improve learning and memory, restore synaptic integrity and reduce amyloid plaque burden in APPSw/Ind mice.

Technical Data

M. Wt 293.39
Formula C17H15N3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 894002-50-7
PubChem ID 7207425
InChI Key DUUQLWDHNYFUPP-UHFFFAOYSA-N
Smiles CC1=CC=CC=C1CSC(N=N3)=CC=C3C2=NC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.34 100
ethanol 5.87 20

Preparing Stock Solutions

The following data is based on the product molecular weight 293.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.41 mL 17.04 mL 34.08 mL
5 mM 0.68 mL 3.41 mL 6.82 mL
10 mM 0.34 mL 1.7 mL 3.41 mL
50 mM 0.07 mL 0.34 mL 0.68 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Lin et al (2012) Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases. Future Med Chem 4 1689 PMID: 22924507

Xing et al (2011) Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg.Med.Chem.Lett. 21 5774 PMID: 21875806

Lin et al (2013) : Mechanism of LDN-212320 induction of glutamate transporter EAAT2 expression . Society for Neuroscience (Abstract) 99 PMID:

Takahashi et al (2013) A small molecule modulator of glutamate transporter EAAT2 ameliorates Alzheimer’s-like pathologies and memory deficits in APPSw/Ind mice. Society for Neuroscience (Abstract) 103 PMID:


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Keywords: LDN 212320, supplier, LDN212320, glutamate, transporters, EAAT2, Excitatory, Amino, Acid, Transporters, Monoamine, Neurotransmitters, Alzheimer's, disease, Glutamate, Transporters, Glutamate, Transporters, Tocris Bioscience

Citations for LDN 212320

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Literature in this Area

Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
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Huntington's Disease Poster

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Schizophrenia Poster

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Pathways for LDN 212320

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