LDN 193188

Pricing Availability Delivery Time Qty
Cat.No. 5631 - LDN 193188 | C20H17Cl2N5O4S | CAS No. 1267610-30-9
Description: Inhibitor of phosphatidylcholine transfer protein (PC-TP)
Chemical Name: 2,4-Dichloro-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]carbonyl]benzamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Inhibitor of phosphatidylcholine transfer protein (PC-TP). Regulates hepatic glucose metabolism. Also promotes insulin-independent phosphorylation of key insulin signaling molecules.

Technical Data

M. Wt 494.35
Formula C20H17Cl2N5O4S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1267610-30-9
PubChem ID 66958626
InChI Key COTBDKMEUUNJTI-UHFFFAOYSA-N
Smiles O=C(NC(NC1=CC=C(S(NC2=NC(C)=CC(C)=N2)(=O)=O)C=C1)=O)C3=C(Cl)C=C(Cl)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 49.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 494.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.11 mL 20.23 mL
5 mM 0.4 mL 2.02 mL 4.05 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Shishova et al (2011) Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production. Hepatology 54 664 PMID: 21538437

Wagle et al (2008) Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening. Anal.Biochem. 383 85 PMID: 18762160


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Keywords: LDN193188 inhibitors inhibits phosphatidylcholine transfer protein PC-TP glucose metabolism insulin Other Lipid Metabolism

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