LDN 193188

Pricing Availability Delivery Time Qty
Cat.No. 5631 - LDN 193188 | C20H17Cl2N5O4S | CAS No. 1267610-30-9
Description: Inhibitor of phosphatidylcholine transfer protein (PC-TP)
Chemical Name: 2,4-Dichloro-N-[[[4-[[(4,6-dimethyl-2-pyrimidinyl)amino]sulfonyl]phenyl]amino]carbonyl]benzamide
Purity: ≥99% (HPLC)

Biological Activity

Inhibitor of phosphatidylcholine transfer protein (PC-TP). Regulates hepatic glucose metabolism. Also promotes insulin-independent phosphorylation of key insulin signaling molecules.

Technical Data

M. Wt 494.35
Formula C20H17Cl2N5O4S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 1267610-30-9
PubChem ID 66958626
Smiles O=C(NC(NC1=CC=C(S(NC2=NC(C)=CC(C)=N2)(=O)=O)C=C1)=O)C3=C(Cl)C=C(Cl)C=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 49.44 100

Preparing Stock Solutions

The following data is based on the product molecular weight 494.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.02 mL 10.11 mL 20.23 mL
5 mM 0.4 mL 2.02 mL 4.05 mL
10 mM 0.2 mL 1.01 mL 2.02 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Shishova et al (2011) Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production. Hepatology 54 664 PMID: 21538437

Wagle et al (2008) Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening. Anal.Biochem. 383 85 PMID: 18762160

If you know of a relevant reference for LDN 193188, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Other Lipid Metabolism Inhibitors

Keywords: LDN193188 inhibitors inhibits phosphatidylcholine transfer protein PC-TP glucose metabolism insulin Other Lipid Metabolism

Citations for LDN 193188

Citations are publications that use Tocris products.

Currently there are no citations for LDN 193188. Do you know of a great paper that uses LDN 193188 from Tocris? If so please let us know.

Commented out for usability testing


TODO: Add Reviews

Literature in this Area

New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

  • 7-TM Receptors
  • Enzymes
  • Enzyme-Linked Receptors
  • Ion Channels
  • Nuclear Receptors
  • Transporters
  • Apoptosis
  • Cell Metabolism
  • Epigenetics
  • Fluorescent Imaging
  • Signal Transduction
  • Stem Cells

Pathways for LDN 193188


TODO: Add Protocols