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Biological Activity for LDN 193188
LDN 193188 is an inhibitor of phosphatidylcholine transfer protein (PC-TP). Regulates hepatic glucose metabolism. Also promotes insulin-independent phosphorylation of key insulin signaling molecules.
Technical Data for LDN 193188
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for LDN 193188
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for LDN 193188
The following data is based on the product molecular weight 494.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.02 mL||10.11 mL||20.23 mL|
|5 mM||0.4 mL||2.02 mL||4.05 mL|
|10 mM||0.2 mL||1.01 mL||2.02 mL|
|50 mM||0.04 mL||0.2 mL||0.4 mL|
References for LDN 193188
References are publications that support the biological activity of the product.
Shishova et al (2011) Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production. Hepatology 54 664 PMID: 21538437
Wagle et al (2008) Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening. Anal.Biochem. 383 85 PMID: 18762160
If you know of a relevant reference for LDN 193188, please let us know.
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Keywords: LDN 193188, LDN 193188 supplier, LDN193188, inhibitors, inhibits, phosphatidylcholine, transfer, protein, PC-TP, glucose, metabolism, insulin, Other, Lipid, Metabolism, 5631, Tocris Bioscience
Citations for LDN 193188
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