L-Buthionine sulfoximine

Pricing Availability   Qty
Cat.No. 6954 - L-Buthionine sulfoximine | C8H18N2O3S | CAS No. 83730-53-4
Description: Irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; induces ferroptosis
Chemical Name: (2S)-2-Amino-4-(S-butylsulfonimidoyl)butanoic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Irreversible γ-glutamylcysteine synthetase (γ-GCS) inhibitor; depletes glutathione levels by inhibiting synthesis. Induces ferroptosis in vitro.

Technical Data

M. Wt 222.3
Formula C8H18N2O3S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 83730-53-4
PubChem ID 119565
InChI Key KJQFBVYMGADDTQ-CVSPRKDYSA-N
Smiles CCCC[S](=N)(=O)CC[C@H](N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 22.23 100
DMSO 22.23 100

Preparing Stock Solutions

The following data is based on the product molecular weight 222.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.5 mL 22.49 mL 44.98 mL
5 mM 0.9 mL 4.5 mL 9 mL
10 mM 0.45 mL 2.25 mL 4.5 mL
50 mM 0.09 mL 0.45 mL 0.9 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References

References are publications that support the biological activity of the product.

Griffith & Meister (1979) Potent and specific inhibition of glutathione synthesis by buthionine sulfoximine (S-n-butyl homocysteine sulfoximine) J.Biol.Chem. 254 7558 PMID: 38242

Griffith et al (1982) Mechanism of action, metabolism, and toxicity of buthionine sulfoximine and its higher homologs, potent inhibitors of glutathione synthesis. J.Biol.Chem. 257 13704 PMID: 6128339

Yang et al (2014) Regulation of ferroptotic cancer cell death by GPX4. Cell. 156 317 PMID: 24439385


If you know of a relevant reference for L-Buthionine sulfoximine, please let us know.

View Related Products by Product Action

View all Other Synthase/Synthetase Inhibitors

Keywords: L-Buthionine sulfoximine, L-Buthionine sulfoximine supplier, Buthionine, sulfoximine, BSO, L-BSO, gamma, glutamylcysteine, synthetase, inhibitors, inhibits, induces, ferroptosis, activiators, activates, g-GCS, glutamate, cysteine, ligase, GSL, Other, Synthases/Synthetases, Ferroptosis, 6954, Tocris Bioscience

Citations for L-Buthionine sulfoximine

Citations are publications that use Tocris products.

Currently there are no citations for L-Buthionine sulfoximine. Do you know of a great paper that uses L-Buthionine sulfoximine from Tocris? Please let us know.

Reviews for L-Buthionine sulfoximine

There are currently no reviews for this product. Be the first to review L-Buthionine sulfoximine and earn rewards!

Have you used L-Buthionine sulfoximine?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis