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Submit ReviewL-803,087 trifluoroacetate
Description: Potent and selective sst4 agonist
Chemical Name: N2-[4-(5,7-Difluoro-2-phenyl-1H-indol-3-yl)-1-oxobutyl]-L-arginine methyl ester trifluoroacetate
Purity: ≥97% (HPLC)
Biological Activity for L-803,087 trifluoroacetate
L-803,087 trifluoroacetate is a potent and selective somatostatin sst4 receptor agonist. Ki values are 0.7, 199, 4720, 1280 and 3880 nM for cloned human sst4, sst1, sst2, sst3 and sst5 receptors respectively. Facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice in vivo.
Technical Data for L-803,087 trifluoroacetate
| M. Wt | 599.56 |
| Formula | C25H29F2N5O3.CF3CO2H |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 1786412-46-1 |
| PubChem ID | 45073436 |
| InChI Key | IIRYZHRNVKQVGQ-BDQAORGHSA-N |
| Smiles | FC(F)(F)C(O)=O.NC(NCCC[C@@H]([C@@](OC)=O)NC(CCCC1=C(C3=CC=CC=C3)NC2=C1C=C(F)C=C2F)=O)=N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for L-803,087 trifluoroacetate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 59.96 | 100 | |
| ethanol | 59.96 | 100 |
Preparing Stock Solutions for L-803,087 trifluoroacetate
The following data is based on the product molecular weight 599.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.67 mL | 8.34 mL | 16.68 mL |
| 5 mM | 0.33 mL | 1.67 mL | 3.34 mL |
| 10 mM | 0.17 mL | 0.83 mL | 1.67 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.33 mL |
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Product Datasheets for L-803,087 trifluoroacetate
References for L-803,087 trifluoroacetate
References are publications that support the biological activity of the product.
Rohrer et al (1998) Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science 282 737 PMID: 9784130
Rohrer and Schaeffer (2000) Identification and characterization of subtype selective somatostatin receptor agonists. J.Physiol.Paris 94 211 PMID: 11087999
Moneta et al (2002) Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice. Eur.J.Neurosci. 16 843 PMID: 12372020
If you know of a relevant reference for L-803,087 trifluoroacetate, please let us know.
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Keywords: L-803,087 trifluoroacetate, L-803,087 trifluoroacetate supplier, Potent, selective, sst4, agonists, Receptors, Somatostatin, L803087, 1979, Tocris Bioscience
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