L-803,087 trifluoroacetate

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Cat.No. 1979 - L-803,087 trifluoroacetate | C25H29F2N5O3.CF3CO2H | CAS No. 217480-26-7
Description: Potent and selective sst4 agonist
Chemical Name: N2-[4-(5,7-Difluoro-2-phenyl-1H-indol-3-yl)-1-oxobutyl]-L-arginine methyl ester trifluoroacetate
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent and selective somatostatin sst4 receptor agonist. Ki values are 0.7, 199, 4720, 1280 and 3880 nM for cloned human sst4, sst1, sst2, sst3 and sst5 receptors respectively. Facilitates AMPA-mediated hippocampal synaptic responses in vitro and increases kainate-induced seizures in mice in vivo.

Technical Data

M. Wt 599.56
Formula C25H29F2N5O3.CF3CO2H
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 217480-26-7
PubChem ID 45073436
InChI Key IIRYZHRNVKQVGQ-BDQAORGHSA-N
Smiles FC(F)(F)C(O)=O.NC(NCCC[C@@H]([C@@](OC)=O)NC(CCCC1=C(C3=CC=CC=C3)NC2=C1C=C(F)C=C2F)=O)=N

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 59.96 100
ethanol 59.96 100

Preparing Stock Solutions

The following data is based on the product molecular weight 599.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.67 mL 8.34 mL 16.68 mL
5 mM 0.33 mL 1.67 mL 3.34 mL
10 mM 0.17 mL 0.83 mL 1.67 mL
50 mM 0.03 mL 0.17 mL 0.33 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Rohrer et al (1998) Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry. Science 282 737 PMID: 9784130

Rohrer and Schaeffer (2000) Identification and characterization of subtype selective somatostatin receptor agonists. J.Physiol.Paris 94 211 PMID: 11087999

Moneta et al (2002) Somatostatin receptor subtypes 2 and 4 affect seizure susceptibility and hippocampal excitatory neurotransmission in mice. Eur.J.Neurosci. 16 843 PMID: 12372020


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