L-701,324

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Cat.No. 0907 - L-701,324 | C21H14ClNO3 | CAS No. 142326-59-8
Description: NMDA antagonist; acts at glycine site
Chemical Name: 7-Chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolinone
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

An orally active and long acting anticonvulsant with high affinity and selectivity for the glycine site on the NMDA receptor.

Licensing Information

Sold with the permission of Merck Sharp and Dohme Ltd.

Compound Libraries

L-701,324 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 363.8
Formula C21H14ClNO3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 142326-59-8
PubChem ID 54682505
InChI Key FLVRDMUHUXVRET-UHFFFAOYSA-N
Smiles OC1=C(C(=O)NC2=CC(Cl)=CC=C12)C1=CC=CC(OC2=CC=CC=C2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 363.8. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.75 mL 13.74 mL 27.49 mL
5 mM 0.55 mL 2.75 mL 5.5 mL
10 mM 0.27 mL 1.37 mL 2.75 mL
50 mM 0.05 mL 0.27 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Bristow et al (1996) The atypical neuroleptic profile of the glycine/N-methyl-D-aspartate receptor antagonist, L-701,324 in rodents. J.Pharmacol.Exp.Ther. 277 578 PMID: 8627534

Bristow et al (1996) Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-methyl-D-aspartate receptor complex. J.Pharmacol.Exp.Ther. 279 492 PMID: 8930150

Kulagowski et al (1994) 3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor. J.Med.Chem. 37 1402 PMID: 8182696

Obrenovitch and Zilkha (1996) Inhibition of cortical spreading depression by L-701,324, a novel antagonist at the glycine site of the N-methyl-D-aspartate receptor complex. Br.J.Pharmacol. 117 931 PMID: 8851513


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Keywords: L-701,324, supplier, NMDA, antagonist, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, L701324, NMDA, Receptors, NMDA, Receptors, Tocris Bioscience

1 Citation for L-701,324

Citations are publications that use Tocris products. Selected citations for L-701,324 include:

Bäckström and Hyytiä (2006) Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology 31 778 PMID: 16123768


Do you know of a great paper that uses L-701,324 from Tocris? If so please let us know.

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