L-670,596

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Cat.No. 1949 - L-670,596 | C22H21F2NO4S | CAS No. 121083-05-4
Description: Potent, selective thromboxane A2/prostaglandin endoperoxide antagonist
Chemical Name: (-)-6-8-Difluoro-2,3,4,9-tetrahydro-9-[[4-(methylsulfonyl)phenyl]methyl]-1H-carbazole-1-acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist (IC50 = 5.5 nM). Inhibits U-44069-induced contractions of guinea pig trachea (pA2 = 9.0) and human platelet aggregation in vitro (IC50 = 6.5 nM). Also prevents thromboxane-mediated endothelial cell death. Orally active in vivo.

Technical Data

M. Wt 433.47
Formula C22H21F2NO4S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 121083-05-4
PubChem ID 129360
InChI Key GMJWAIMJHBTYPD-UHFFFAOYSA-N
Smiles CS(=O)(=O)C1=CC=C(CN2C3=C(CCCC3CC(O)=O)C3=CC(F)=CC(F)=C23)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 43.35 100

Preparing Stock Solutions

The following data is based on the product molecular weight 433.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.31 mL 11.53 mL 23.07 mL
5 mM 0.46 mL 2.31 mL 4.61 mL
10 mM 0.23 mL 1.15 mL 2.31 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References

References are publications that support the biological activity of the product.

Ford-Hutchinson et al (1989) The pharmacology of L-670,596, a potent and selective thromboxane/prostaglandin endoperoxide receptor antagonist. Can.J.Physiol.Pharmacol. 67 989 PMID: 2598135

Girard et al (1989) Tetrahydrocarbazol-1-acetic acids: new class of thromboxane receptor antagonists. Prog.Clin.Biol.Res. 301 585 PMID: 2529558

Beauchamp et al (2001) Role of thromboxane in retinal microvascular degeneration in oxygen-induced retinopathy. J.Appl.Physiol. 90 2279 PMID: 11356793


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Keywords: L-670,596, L-670,596 supplier, Potent, selective, thromboxane, A2, endoperoxide, antagonists, TP, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, L670596, Receptors, 1949, Tocris Bioscience

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