L-655,240

Discontinued Product

Unfortunately L-655,240 (Cat. No. 1698) has been withdrawn from sale for commercial reasons.
Cat.No. 1698 - L-655,240 | C21H21ClFNO2 | CAS No. 103253-15-2
Description: Potent, selective thromboxane A2/prostaglandin endoperoxide antagonist
Chemical Name: 1-[(4-Chlorophenyl)methyl]-5-fluoro-α,α,3-trimethyl-1H-indole-2-propanoic acid
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Literature

Biological Activity

Potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist. pA2 values are 8 - 8.4 in guinea pig smooth muscle; IC50 = 7 nM for inhibition of human platelet aggregation. Orally active in vivo.

Compound Libraries

L-655,240 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 373.85
Formula C21H21ClFNO2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 103253-15-2
PubChem ID 122070
InChI Key JLPYLHLUHJOPNL-UHFFFAOYSA-N
Smiles CC1=C(CC(C)(C)C(O)=O)N(CC2=CC=C(Cl)C=C2)C2=CC=C(F)C=C12

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 373.85. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.37 mL 26.75 mL
5 mM 0.53 mL 2.67 mL 5.35 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hall et al (1987) Pharmacology of L-655,240 (3-[1-(4-chlorobenzyl)-5-fluoro-3-methyl-indol-2-yl]2,2-dimethylpropanoic acid); a potent, selective thomboxane / prostaglandin endoperoxide antagonist. Eur.J.Pharmacol. 135 193 PMID: 3582493

Ogletree and Allen (1992) Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J.Pharmacol.Exp.Ther. 260 789 PMID: 1531361

Wainright and Parratt (1988) The effects of L655,240, a selective thromboxane and prostaglandin endoperoxide antagonist, on ischemia- and reperfusion-induced cardiac arrhythmias. J.Cardiovasc.Pharmacol. 12 264 PMID: 2464097

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Keywords: L-655,240, supplier, Potent, selective, thromboxane, A2, endoperoxide, TP, antagonists, Prostanoid, prostaglandins, prostacyclins, eicosanoids, L655240, Prostanoid, Receptors, Tocris Bioscience

1 Citation for L-655,240

Citations are publications that use Tocris products. Selected citations for L-655,240 include:

Wong et al (2009) Cyclooxygenase-2-derived prostaglandin F2alpha mediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging. Circ Res 104 228 PMID: 19096033


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Pathways for L-655,240

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