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KL 001

Cat. No. 4685 Submit a Review Datasheet / COA / SDS
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Cat.No. 4685 - KL 001 | C21H22N2O4S | CAS No. 309928-48-1
Description: Cryptochrome protein stabilizer; lengthens circadian period
Chemical Name: N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
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Literature
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity

Cryptochrome protein (CRY) stabilizer; blocks proteasome-mediated degradation of CRY1 and CRY2. Lengthens circadian period in mouse NIH-3T3 fibroblasts without altering casein kinase activity. Represses glucagon-induced hepatic gluconeogenesis through the induction of Pck1 and G6pc expression.

Compound Libraries

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Technical Data

M. Wt 398.48
Formula C21H22N2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 309928-48-1
PubChem ID 2888648
InChI Key OQAFDLPAPSSOHY-UHFFFAOYSA-N
Smiles OC(CN(CC4=CC=CO4)S(C)(=O)=O)CN2C1=CC=CC=C1C3=C2C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.85 100
ethanol 7.97 20

Preparing Stock Solutions

The following data is based on the product molecular weight 398.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.55 mL 25.1 mL
5 mM 0.5 mL 2.51 mL 5.02 mL
10 mM 0.25 mL 1.25 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References

References are publications that support the biological activity of the product.

Hirota et al (2012) Identification of small molecule activators of cryptochrome. Science 337 1094 PMID: 22798407

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Keywords: KL 001, KL 001 supplier, KL001, cryptochrome, stabilizers, CRY, CRY1, CRY2, circadian, clock, rhythms, gluconeogenesis, regulator, Other, Transcription, Factors, 4685, Tocris Bioscience

Citations for KL 001

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