KL 001
Biological Activity
Cryptochrome protein (CRY) stabilizer; blocks proteasome-mediated degradation of CRY1 and CRY2. Lengthens circadian period in mouse NIH-3T3 fibroblasts without altering casein kinase activity. Represses glucagon-induced hepatic gluconeogenesis through the induction of Pck1 and G6pc expression.
Compound Libraries
KL 001 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 398.48 |
| Formula | C21H22N2O4S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 309928-48-1 |
| PubChem ID | 2888648 |
| InChI Key | OQAFDLPAPSSOHY-UHFFFAOYSA-N |
| Smiles | OC(CN(CC4=CC=CO4)S(C)(=O)=O)CN2C1=CC=CC=C1C3=C2C=CC=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.85 | 100 | |
| ethanol | 7.97 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 398.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.51 mL | 12.55 mL | 25.1 mL |
| 5 mM | 0.5 mL | 2.51 mL | 5.02 mL |
| 10 mM | 0.25 mL | 1.25 mL | 2.51 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Hirota et al (2012) Identification of small molecule activators of cryptochrome. Science 337 1094 PMID: 22798407
If you know of a relevant reference for KL 001, please let us know.
View Related Products by Target
Keywords: KL001 cryptochrome stabilizers CRY CRY1 CRY2 circadian clock rhythms gluconeogenesis regulator Other Transcription Factors
Citations for KL 001
Citations are publications that use Tocris products.
Currently there are no citations for KL 001. Do you know of a great paper that uses KL 001 from Tocris? If so please let us know.
Literature in this Area
New Product Guide (Spring/Summer 2017)New
Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.
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