KL 001

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Cat.No. 4685 - KL 001 | C21H22N2O4S | CAS No. 309928-48-1
Description: Cryptochrome protein stabilizer; lengthens circadian period
Chemical Name: N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide
Purity: ≥98% (HPLC)

Biological Activity for KL 001

KL 001 is a cryptochrome protein (CRY) stabilizer; blocks proteasome-mediated degradation of CRY1 and CRY2. Lengthens circadian period in mouse NIH-3T3 fibroblasts without altering casein kinase activity. Represses glucagon-induced hepatic gluconeogenesis through the induction of Pck1 and G6pc expression.

Technical Data for KL 001

M. Wt 398.48
Formula C21H22N2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 309928-48-1
PubChem ID 2888648
Smiles OC(CN(CC4=CC=CO4)S(C)(=O)=O)CN2C1=CC=CC=C1C3=C2C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for KL 001

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 39.85 100
ethanol 7.97 20

Preparing Stock Solutions for KL 001

The following data is based on the product molecular weight 398.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.55 mL 25.1 mL
5 mM 0.5 mL 2.51 mL 5.02 mL
10 mM 0.25 mL 1.25 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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References for KL 001

References are publications that support the biological activity of the product.

Hirota et al (2012) Identification of small molecule activators of cryptochrome. Science 337 1094 PMID: 22798407

If you know of a relevant reference for KL 001, please let us know.

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Keywords: KL 001, KL 001 supplier, KL001, cryptochrome, stabilizers, CRY, CRY1, CRY2, circadian, clock, rhythms, gluconeogenesis, regulator, Other, Transcription, Factors, 4685, Tocris Bioscience

Citations for KL 001

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