KL 001
Biological Activity
Cryptochrome protein (CRY) stabilizer; blocks proteasome-mediated degradation of CRY1 and CRY2. Lengthens circadian period in mouse NIH-3T3 fibroblasts without altering casein kinase activity. Represses glucagon-induced hepatic gluconeogenesis through the induction of Pck1 and G6pc expression.
Compound Libraries
KL 001 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
Technical Data
M. Wt | 398.48 |
Formula | C21H22N2O4S |
Storage | Store at +4°C |
Purity | ≥98% (HPLC) |
CAS Number | 309928-48-1 |
PubChem ID | 2888648 |
InChI Key | OQAFDLPAPSSOHY-UHFFFAOYSA-N |
Smiles | OC(CN(CC4=CC=CO4)S(C)(=O)=O)CN2C1=CC=CC=C1C3=C2C=CC=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 39.85 | 100 | |
ethanol | 7.97 | 20 |
Preparing Stock Solutions
The following data is based on the product molecular weight 398.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.51 mL | 12.55 mL | 25.1 mL |
5 mM | 0.5 mL | 2.51 mL | 5.02 mL |
10 mM | 0.25 mL | 1.25 mL | 2.51 mL |
50 mM | 0.05 mL | 0.25 mL | 0.5 mL |
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Product Datasheets
References
References are publications that support the biological activity of the product.
Hirota et al (2012) Identification of small molecule activators of cryptochrome. Science 337 1094 PMID: 22798407
If you know of a relevant reference for KL 001, please let us know.
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Keywords: KL 001, KL 001 supplier, KL001, cryptochrome, stabilizers, CRY, CRY1, CRY2, circadian, clock, rhythms, gluconeogenesis, regulator, Other, Transcription, Factors, 4685, Tocris Bioscience
Citations for KL 001
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Literature in this Area
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