KL 001

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Cat.No. 4685 - KL 001 | C21H22N2O4S | CAS No. 309928-48-1
Description: Cryptochrome protein stabilizer; lengthens circadian period
Chemical Name: N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Cryptochrome protein (CRY) stabilizer; blocks proteasome-mediated degradation of CRY1 and CRY2. Lengthens circadian period in mouse NIH-3T3 fibroblasts without altering casein kinase activity. Represses glucagon-induced hepatic gluconeogenesis through the induction of Pck1 and G6pc expression.

Compound Libraries

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Technical Data

M. Wt 398.48
Formula C21H22N2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 309928-48-1
PubChem ID 2888648
InChI Key OQAFDLPAPSSOHY-UHFFFAOYSA-N
Smiles OC(CN(CC4=CC=CO4)S(C)(=O)=O)CN2C1=CC=CC=C1C3=C2C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 39.85 100
ethanol 7.97 20

Preparing Stock Solutions

The following data is based on the product molecular weight 398.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.51 mL 12.55 mL 25.1 mL
5 mM 0.5 mL 2.51 mL 5.02 mL
10 mM 0.25 mL 1.25 mL 2.51 mL
50 mM 0.05 mL 0.25 mL 0.5 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Hirota et al (2012) Identification of small molecule activators of cryptochrome. Science 337 1094 PMID: 22798407


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Keywords: KL001 cryptochrome stabilizers CRY CRY1 CRY2 circadian clock rhythms gluconeogenesis regulator Other Transcription Factors

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New Product Guide

New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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  • Signal Transduction
  • Stem Cells

Pathways for KL 001

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