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Submit ReviewKCC 07
Discontinued Product
KCC 07 (Cat. No. 6615) has been withdrawn from sale for commercial reasons.
Description: MBD2 (Methyl-CpG-binding domain protein 2) inhibitor
Chemical Name: 3-[[4-(2-Pyridinyl)-2-thiazolyl]amino]phenol
Purity: ≥98% (HPLC)
Biological Activity for KCC 07
KCC 07 is a MBD2 (Methyl-CpG-binding domain protein 2) inhibitor. Prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. Inhibits medulloblastoma (MB) cell growth in vitro and reduces tumor size in mice bearing MB xenografts. Brain penetrant.
Technical Data for KCC 07
| M. Wt | 269.32 |
| Formula | C14H11N3OS |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 315702-75-1 |
| PubChem ID | 704347 |
| InChI Key | GIGNWEDIMLUWCT-UHFFFAOYSA-N |
| Smiles | OC1=CC=CC(NC2=NC(C3=CC=CC=N3)=CS2)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for KCC 07
References for KCC 07
References are publications that support the biological activity of the product.
Zhu et al (2018) BAI1 suppresses medulloblastoma formation by protecting p53 from Mdm2-mediated degradation. Cancer Cell 33 1004 PMID: 29894688
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Keywords: KCC 07, KCC 07 supplier, KCC07, MBD2, inhibitors, inhibits, Methyl-CpG-binding, domain, protein, 2, medulloblastoma, BAI1, p53, signaling, activators, activates, DNA, Methyltransferases, 6615, Tocris Bioscience
Citations for KCC 07
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Currently there are no citations for KCC 07.
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Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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