KCC 07

Discontinued Product

KCC 07 (Cat. No. 6615) has been withdrawn from sale for commercial reasons.
Description: MBD2 (Methyl-CpG-binding domain protein 2) inhibitor
Chemical Name: 3-[[4-(2-Pyridinyl)-2-thiazolyl]amino]phenol
Purity: ≥98% (HPLC)
Literature (3)

Biological Activity for KCC 07

KCC 07 is a MBD2 (Methyl-CpG-binding domain protein 2) inhibitor. Prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. Inhibits medulloblastoma (MB) cell growth in vitro and reduces tumor size in mice bearing MB xenografts. Brain penetrant.

Technical Data for KCC 07

M. Wt 269.32
Formula C14H11N3OS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 315702-75-1
PubChem ID 704347
Smiles OC1=CC=CC(NC2=NC(C3=CC=CC=N3)=CS2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for KCC 07

References are publications that support the biological activity of the product.

Zhu et al (2018) BAI1 suppresses medulloblastoma formation by protecting p53 from Mdm2-mediated degradation. Cancer Cell 33 1004 PMID: 29894688

Keywords: KCC 07, KCC 07 supplier, KCC07, MBD2, inhibitors, inhibits, Methyl-CpG-binding, domain, protein, 2, medulloblastoma, BAI1, p53, signaling, activators, activates, DNA, Methyltransferases, 6615, Tocris Bioscience

Citations for KCC 07

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Currently there are no citations for KCC 07.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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