KCC 07

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Cat.No. 6615 - KCC 07 | C14H11N3OS | CAS No. 315702-75-1
Description: MBD2 (Methyl-CpG-binding domain protein 2) inhibitor
Chemical Name: 3-[[4-(2-Pyridinyl)-2-thiazolyl]amino]phenol
Purity: ≥98% (HPLC)
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Citations
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Literature

Biological Activity

MBD2 (Methyl-CpG-binding domain protein 2) inhibitor. Prevents binding of MBD2 to methylated DNA and activates brain specific angiogenesis inhibitor 1 (BAI1)/p53 signaling. Inhibits medulloblastoma (MB) cell growth in vitro and reduces tumor size in mice bearing MB xenografts. Brain penetrant.

Technical Data

M. Wt 269.32
Formula C14H11N3OS
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 315702-75-1
PubChem ID 704347
InChI Key GIGNWEDIMLUWCT-UHFFFAOYSA-N
Smiles OC1=CC=CC(NC2=NC(C3=CC=CC=N3)=CS2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 26.93 100
ethanol 5.39 20

Preparing Stock Solutions

The following data is based on the product molecular weight 269.32. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.71 mL 18.57 mL 37.13 mL
5 mM 0.74 mL 3.71 mL 7.43 mL
10 mM 0.37 mL 1.86 mL 3.71 mL
50 mM 0.07 mL 0.37 mL 0.74 mL

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References

References are publications that support the biological activity of the product.

Zhu et al (2018) BAI1 suppresses medulloblastoma formation by protecting p53 from Mdm2-mediated degradation. Cancer Cell 33 1004 PMID: 29894688


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Keywords: KCC 07, KCC 07 supplier, KCC07, MBD2, inhibitors, inhibits, Methyl-CpG-binding, domain, protein, 2, medulloblastoma, BAI1, p53, signaling, activators, activates, DNA, Methyltransferases, 6615, Tocris Bioscience

Citations for KCC 07

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