Discontinued Product

K-(D-1-Nal)-FwLL-NH2 (Cat. No. 5830) has been withdrawn from sale for commercial reasons.
Description: High affinity and potent ghrelin receptor inverse agonist
Literature (1)

Biological Activity for K-(D-1-Nal)-FwLL-NH2

K-(D-1-Nal)-FwLL-NH2 is a high affinity and potent ghrelin receptor inverse agonist (Ki values are 4.9 and 31 nM in COS7 and HEK293T cells, respectively). Blocks ghrelin receptor-mediated Gq- and G13-dependent signaling pathways.

Technical Data for K-(D-1-Nal)-FwLL-NH2

M. Wt 902.13
Formula C51H67N9O6
Sequence KXFWLL

(Modifications: X=D-1-Nal,Trp-4 = D-Trp, Leu-6 = C-terminal amide)

Storage Store at -20°C
CAS Number 1394288-22-2
PubChem ID 71453489
Smiles [H]N[C@@H](CCCCN)C(=O)N[C@H](CC1=CC=CC2=C1C=CC=C2)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for K-(D-1-Nal)-FwLL-NH2

References for K-(D-1-Nal)-FwLL-NH2

References are publications that support the biological activity of the product.

Els et al (2012) An aromatic region to induce a switch between agonism and inverse agonism at the ghrelin receptor. J.Med.Chem. 55 7437 PMID: 22920150

M'Kadmi et al (2015) Agonism, antagonism, and inverse agonism bias at the ghrelin receptor signaling. J.Biol.Chem. 290 27021 PMID: 26363071

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Keywords: K-(D-1-Nal)-FwLL-NH2, K-(D-1-Nal)-FwLL-NH2 supplier, ghrelin, receptors, inverse, agonists, agonism, peptide, potent, high, affinity, Ghrelin, Receptors, 5830, Tocris Bioscience

Citations for K-(D-1-Nal)-FwLL-NH2

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Currently there are no citations for K-(D-1-Nal)-FwLL-NH2.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.