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Submit ReviewJWH 018
Description: Potent CB1 and CB2 agonist
Chemical Name: (1-Pentyl-1H-indol-3-yl)-1-naphthalenylmethanone
Purity: ≥99% (HPLC)
Biological Activity for JWH 018
Potent cannabinoid receptor agonist with mild selectivity for CB2 (Ki values are 2.94 and 9.0 nM for CB2 and CB1 receptors respectively).
Technical Data for JWH 018
| M. Wt | 341.45 |
| Formula | C24H23NO |
| Storage | Desiccate at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 209414-07-3 |
| PubChem ID | 10382701 |
| InChI Key | JDNLPKCAXICMBW-UHFFFAOYSA-N |
| Smiles | O=C(C3=CN(CCCCC)C4=C3C=CC=C4)C1=CC=CC2=C1C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for JWH 018
References for JWH 018
References are publications that support the biological activity of the product.
Aung et al (2000) Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug Alcohol Depend. 60 133 PMID: 10940540
Chin et al (1999) The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor. J.Pharmacol.Exp.Ther. 291 837 PMID: 10525107
Huffman et al (2003) 3-Indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor. Bioorg.Med.Chem. 11 539 PMID: 12538019
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Keywords: JWH 018, JWH 018 supplier, Potent, CB1, CB2, agonists, Cannabinoids, Non-Selective, Receptors, JWH018, cb2r, cb1r, Non-selective, 1342, Tocris Bioscience
1 Citation for JWH 018
Citations are publications that use Tocris products. Selected citations for JWH 018 include:
Ford (2017) Characterization of structurally novel G protein biased CB1 agonists: implications for drug development. Pharmacol Res 125 161 PMID: 28838808
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.