Potent cannabinoid receptor agonist with mild selectivity for CB2 (Ki values are 2.94 and 9.0 nM for CB2 and CB1 receptors respectively).
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 341.45. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.93 mL||14.64 mL||29.29 mL|
|5 mM||0.59 mL||2.93 mL||5.86 mL|
|10 mM||0.29 mL||1.46 mL||2.93 mL|
|50 mM||0.06 mL||0.29 mL||0.59 mL|
References are publications that support the biological activity of the product.
Aung et al (2000) Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug Alcohol Depend. 60 133 PMID: 10940540
Chin et al (1999) The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor. J.Pharmacol.Exp.Ther. 291 837 PMID: 10525107
Huffman et al (2003) 3-Indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor. Bioorg.Med.Chem. 11 539 PMID: 12538019
If you know of a relevant reference for JWH 018, please let us know.
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Keywords: JWH 018, JWH 018 supplier, Potent, CB1, CB2, agonists, Cannabinoids, Non-Selective, Receptors, JWH018, cb2r, cb1r, Non-selective, 1342, Tocris Bioscience
1 Citation for JWH 018
Citations are publications that use Tocris products. Selected citations for JWH 018 include:
Ford (2017) Characterization of structurally novel G protein biased CB1 agonists: implications for drug development. Pharmacol Res 125 161 PMID: 28838808
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Literature in this Area
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