JWH 018

Discontinued Product

JWH 018 (Cat. No. 1342) has been withdrawn from sale for commercial reasons.
Cat.No. 1342 - JWH 018 | C24H23NO | CAS No. 209414-07-3
Description: Potent CB1 and CB2 agonist
Chemical Name: (1-Pentyl-1H-indol-3-yl)-1-naphthalenylmethanone
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (4)

Biological Activity

Potent cannabinoid receptor agonist with mild selectivity for CB2 (Ki values are 2.94 and 9.0 nM for CB2 and CB1 receptors respectively).

Technical Data

M. Wt 341.45
Formula C24H23NO
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 209414-07-3
PubChem ID 10382701
InChI Key JDNLPKCAXICMBW-UHFFFAOYSA-N
Smiles O=C(C3=CN(CCCCC)C4=C3C=CC=C4)C1=CC=CC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Aung et al (2000) Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug Alcohol Depend. 60 133 PMID: 10940540

Chin et al (1999) The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor. J.Pharmacol.Exp.Ther. 291 837 PMID: 10525107

Huffman et al (2003) 3-Indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor. Bioorg.Med.Chem. 11 539 PMID: 12538019

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Keywords: JWH 018, JWH 018 supplier, Potent, CB1, CB2, agonists, Cannabinoids, Non-Selective, Receptors, JWH018, cb2r, cb1r, Non-selective, 1342, Tocris Bioscience

1 Citation for JWH 018

Citations are publications that use Tocris products. Selected citations for JWH 018 include:

Ford (2017) Characterization of structurally novel G protein biased CB1 agonists: implications for drug development. Pharmacol Res 125 161 PMID: 28838808


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