JWH 018

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Cat.No. 1342 - JWH 018 | C24H23NO | CAS No. 209414-07-3
Description: Potent CB1 and CB2 agonist
Chemical Name: (1-Pentyl-1H-indol-3-yl)-1-naphthalenylmethanone
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent cannabinoid receptor agonist with mild selectivity for CB2 (Ki values are 2.94 and 9.0 nM for CB2 and CB1 receptors respectively).

Technical Data

M. Wt 341.45
Formula C24H23NO
Storage Desiccate at -20°C
Purity ≥99% (HPLC)
CAS Number 209414-07-3
PubChem ID 10382701
InChI Key JDNLPKCAXICMBW-UHFFFAOYSA-N
Smiles O=C(C3=CN(CCCCC)C4=C3C=CC=C4)C1=CC=CC2=C1C=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.15 100
ethanol 34.15 100

Preparing Stock Solutions

The following data is based on the product molecular weight 341.45. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.93 mL 14.64 mL 29.29 mL
5 mM 0.59 mL 2.93 mL 5.86 mL
10 mM 0.29 mL 1.46 mL 2.93 mL
50 mM 0.06 mL 0.29 mL 0.59 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Aung et al (2000) Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB1 and CB2 receptor binding. Drug Alcohol Depend. 60 133 PMID: 10940540

Chin et al (1999) The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor. J.Pharmacol.Exp.Ther. 291 837 PMID: 10525107

Huffman et al (2003) 3-Indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB1 cannabinoid receptor. Bioorg.Med.Chem. 11 539 PMID: 12538019


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Keywords: JWH 018, supplier, Potent, CB1, CB2, agonists, Cannabinoids, Non-Selective, Receptors, JWH018, cb2r, cb1r, Non-selective, Cannabinoids, Tocris Bioscience

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