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Cat.No. 5853 - JNJ DGAT2-A | C24H16BrFN4O2S | CAS No. 1962931-71-0
Description: DGAT2 inhibitor
Chemical Name: 3-Bromo-4-[2-fluoro-4-[[4-oxo-2-[[2-(pyridin-2-yl)ethyl]amino]-1,3-thiazol-5-(4H)ylidene]methyl]phenoxy]benzonitrile

Biological Activity

DGAT2 inhibitor (IC50 = 140 nM). Exhibits >70-fold selectivity for DGAT2 over DGAT1 and MGAT2.

Technical Data

M. Wt 523.38
Formula C24H16BrFN4O2S
Storage Store at +4°C
CAS Number 1962931-71-0
PubChem ID 101578741
Smiles BrC1=C(OC2=C(F)C=C(/C=C3\SC(NCCC4=CC=CC=N4)=NC3=O)C=C2)C=CC(C#N)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 52.34 100

Preparing Stock Solutions

The following data is based on the product molecular weight 523.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.55 mL 19.11 mL
5 mM 0.38 mL 1.91 mL 3.82 mL
10 mM 0.19 mL 0.96 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Qi et al (2012) The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2 J.Lipid Res. 53 1106 PMID: 22493088

Irshad et al (2017) Diacylglycerol acyltransferase 2 links glucose utilization to fatty acid oxidation in the brown adipocytes. J.Lipid Res. 58 15 PMID: 27836993

If you know of a relevant reference for JNJ DGAT2-A, please let us know.

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Keywords: JNJDGAT2-A Diacylglycerol O-Acyltransferases DGAT2 inhibitors inhibits DGAT-2iJ Diacylglycerol O-Acyltransferase

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