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Description: DGAT2 inhibitor
Chemical Name: 3-Bromo-4-[2-fluoro-4-[[4-oxo-2-[[2-(pyridin-2-yl)ethyl]amino]-1,3-thiazol-5-(4H)ylidene]methyl]phenoxy]benzonitrile

Biological Activity for JNJ DGAT2-A

JNJ DGAT2-A is a DGAT2 inhibitor (IC50 = 140 nM). Exhibits >70-fold selectivity for DGAT2 over DGAT1 and MGAT2.

Technical Data for JNJ DGAT2-A

M. Wt 523.38
Formula C24H16BrFN4O2S
Storage Store at +4°C
CAS Number 1962931-71-0
PubChem ID 101578741
Smiles BrC1=C(OC2=C(F)C=C(/C=C3\SC(NCCC4=CC=CC=N4)=NC3=O)C=C2)C=CC(C#N)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for JNJ DGAT2-A

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 52.34 100

Preparing Stock Solutions for JNJ DGAT2-A

The following data is based on the product molecular weight 523.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.91 mL 9.55 mL 19.11 mL
5 mM 0.38 mL 1.91 mL 3.82 mL
10 mM 0.19 mL 0.96 mL 1.91 mL
50 mM 0.04 mL 0.19 mL 0.38 mL

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References for JNJ DGAT2-A

References are publications that support the biological activity of the product.

Qi et al (2012) The use of stable isotope-labeled glycerol and oleic acid to differentiate the hepatic functions of DGAT1 and -2 J.Lipid Res. 53 1106 PMID: 22493088

Irshad et al (2017) Diacylglycerol acyltransferase 2 links glucose utilization to fatty acid oxidation in the brown adipocytes. J.Lipid Res. 58 15 PMID: 27836993

If you know of a relevant reference for JNJ DGAT2-A, please let us know.

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Citations for JNJ DGAT2-A

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