Ipratropium bromide

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Cat.No. 0692 - Ipratropium bromide | C20H30BrNO3 | CAS No. 22254-24-6
Description: Muscarinic antagonist
Chemical Name: (endo,syn)-(±)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane bromide
Purity: ≥98% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Muscarinic antagonist, bronchodilator. N-Isopropyl salt of atropine.

Technical Data

M. Wt 412.37
Formula C20H30BrNO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 22254-24-6
PubChem ID 31098
InChI Key LHLMOSXCXGLMMN-UHFFFAOYSA-M
Smiles O=C(C(CO)C3=CC=CC=C3)O[C@@H]1CC2CCC([N+](C)2C(C)C)C1.[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.24 100mM with gentle warming
water 20.62 50

Preparing Stock Solutions

The following data is based on the product molecular weight 412.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.43 mL 12.13 mL 24.25 mL
5 mM 0.49 mL 2.43 mL 4.85 mL
10 mM 0.24 mL 1.21 mL 2.43 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Molarity Calculator

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Reconstitution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Fryer and Maclagan (1987) Ipratropium bromide potentiates bronchoconstriction induced by vagal nerve stimulation in the guinea-pig. Eur.J.Pharmacol. 139 187 PMID: 2958300

Merck Index 12 5089 PMID:


If you know of a relevant reference for Ipratropium bromide, please let us know.

View Related Products by Product Action

View all Non-selective Muscarinic Antagonists

Keywords: Ipratropium bromide, supplier, Muscarinic, antagonists, Receptors, Acetylcholine, bronchodilator, ACh, Non-selective, Muscarinics, Non-selective, Muscarinics, Tocris Bioscience

2 Citations for Ipratropium bromide

Citations are publications that use Tocris products. Selected citations for Ipratropium bromide include:

Valeria et al (2016) A subnanomolar concentration of Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) pre-synaptically modulates glutamatergic transmission in the rat hippocampus acting through acetylcholine Neuroscience 340 551 PMID: 27816700

Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572


Do you know of a great paper that uses Ipratropium bromide from Tocris? If so please let us know.

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