Ipratropium bromide

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Cat.No. 0692 - Ipratropium bromide | C20H30BrNO3 | CAS No. 22254-24-6
Description: Muscarinic antagonist
Chemical Name: (endo,syn)-(±)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane bromide
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Reviews
Literature

Biological Activity

Muscarinic antagonist, bronchodilator. N-Isopropyl salt of atropine.

Technical Data

M. Wt 412.37
Formula C20H30BrNO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 22254-24-6
PubChem ID 31098
InChI Key LHLMOSXCXGLMMN-UHFFFAOYSA-M
Smiles O=C(C(CO)C3=CC=CC=C3)O[C@@H]1CC2CCC([N+](C)2C(C)C)C1.[Br-]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 20.62 50

Preparing Stock Solutions

The following data is based on the product molecular weight 412.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 4.85 mL 24.25 mL 48.5 mL
2.5 mM 0.97 mL 4.85 mL 9.7 mL
5 mM 0.49 mL 2.43 mL 4.85 mL
25 mM 0.1 mL 0.49 mL 0.97 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Fryer and Maclagan (1987) Ipratropium bromide potentiates bronchoconstriction induced by vagal nerve stimulation in the guinea-pig. Eur.J.Pharmacol. 139 187 PMID: 2958300

Merck Index 12 5089


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View Related Products by Product Action

View all Non-selective Muscarinic Antagonists

Keywords: Ipratropium bromide, Ipratropium bromide supplier, Muscarinic, antagonists, Receptors, Acetylcholine, bronchodilator, ACh, Non-selective, Muscarinics, 0692, Tocris Bioscience

3 Citations for Ipratropium bromide

Citations are publications that use Tocris products. Selected citations for Ipratropium bromide include:

Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572

Valeria et al (2016) A subnanomolar concentration of Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) pre-synaptically modulates glutamatergic transmission in the rat hippocampus acting through acetylcholine Neuroscience 340 551 PMID: 27816700

Deng et al (2013) Label-free cell phenotypic assessment of the biased agonism and efficacy of agonists at the endogenous muscarinic M3 receptors. J Pharmacol Toxicol Methods 68 323 PMID: 23933114


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