Prostacyclin (PGI2) analog that binds with high affinity to IP, EP1 and EP3 receptors (Ki values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP1, EP3, EP4, FP, DP, EP2 and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC50 values are 0.24, 0.71 and 1.07 nM respectively).
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble in methyl acetate (supplied pre-dissolved - 5mg/ml)|
Preparing Stock Solutions
The following data is based on the product molecular weight 360.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.77 mL||13.87 mL||27.74 mL|
|5 mM||0.55 mL||2.77 mL||5.55 mL|
|10 mM||0.28 mL||1.39 mL||2.77 mL|
|50 mM||0.06 mL||0.28 mL||0.55 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Della Bella et al (2001) Novel mode of action of iloprost: in vitro down-regulaton of endothelial cell adhesion molecules. Prostaglandins Other Lipid Mediat. 65 73 PMID: 11403500
Abramovitz et al (2000) The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim.Biophys.Acta 1483 285 PMID: 10634944
If you know of a relevant reference for Iloprost, please let us know.
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Keywords: Prostacyclin PGI2 IP EP1 EP3 Receptors Prostaglandin Prostanoid prostaglandins prostacyclins eicosanoids ZK36374 ZK 36374 Prostanoid Receptors
2 Citations for Iloprost
Citations are publications that use Tocris products. Selected citations for Iloprost include:
Lee and Diamond (2015) A human platelet calcium calculator trained by pairwise agonist scanning. Nat Commun 11 e1004118 PMID: 25723389
Flamm et al (2012) Multiscale prediction of patient-specific platelet function under flow. Blood 120 190 PMID: 22517902
Do you know of a great paper that uses Iloprost from Tocris? If so please let us know.
Literature in this Area
Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.