Iloprost

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Cat.No. 2038 - Iloprost | C22H32O4 | CAS No. 78919-13-8
Description: Prostacyclin (PGI2) analog
Alternative Names: ZK 36374
Chemical Name: (5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]pentanoic acid
Purity: ≥97% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Prostacyclin (PGI2) analog that binds with high affinity to IP, EP1 and EP3 receptors (Ki values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP1, EP3, EP4, FP, DP, EP2 and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC50 values are 0.24, 0.71 and 1.07 nM respectively).

Technical Data

M. Wt 360.49
Formula C22H32O4
Storage Desiccate at -20°C
Purity ≥97% (HPLC)
CAS Number 78919-13-8
PubChem ID 5311181
InChI Key HIFJCPQKFCZDDL-ACWOEMLNSA-N
Smiles O[C@@H]1C[C@H]2[C@H](C/C(C2)=C/CCCC(O)=O)[C@H]1/C=C/[C@@H](O)C(C)CC#CC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in methyl acetate (supplied pre-dissolved - 5mg/ml)

Preparing Stock Solutions

The following data is based on the product molecular weight 360.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.87 mL 27.74 mL
5 mM 0.55 mL 2.77 mL 5.55 mL
10 mM 0.28 mL 1.39 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Della Bella et al (2001) Novel mode of action of iloprost: in vitro down-regulaton of endothelial cell adhesion molecules. Prostaglandins Other Lipid Mediat. 65 73 PMID: 11403500

Abramovitz et al (2000) The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochim.Biophys.Acta 1483 285 PMID: 10634944

Schror et al (1981) The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374) - equipotent to PGI2 in vitro. Naunyn-Schmied.Arch.Pharmacol. 316 252 PMID:


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Keywords: Prostacyclin PGI2 IP EP1 EP3 Receptors Prostaglandin Prostanoid prostaglandins prostacyclins eicosanoids ZK36374 ZK 36374 Prostanoid Receptors

2 Citations for Iloprost

Citations are publications that use Tocris products. Selected citations for Iloprost include:

Lee and Diamond (2015) A human platelet calcium calculator trained by pairwise agonist scanning. Nat Commun 11 e1004118 PMID: 25723389

Flamm et al (2012) Multiscale prediction of patient-specific platelet function under flow. Blood 120 190 PMID: 22517902


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