ICI 185,282

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Cat.No. 0836 - ICI 185,282 | C18H21F3O5 | CAS No. 106393-80-0
Description: Potent thromboxane receptor antagonist
Chemical Name: 5-(Z)-7-(4-o-Hydroxyphenyl-2-trifluoromethyl-1,3 dioxan-cis-5-yl)heptenoic acid
Datasheet
Citations (1)
Literature

Biological Activity

Potent thromboxane receptor antagonist.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 374.36
Formula C18H21F3O5
Storage Desiccate at -20°C
CAS Number 106393-80-0
PubChem ID 5311390
InChI Key ZWAVGFSZMACJHA-PMNBYGLBSA-N
Smiles OC(=O)CCC\C=C/C[C@@H]1CO[C@@H](O[C@@H]1C1=C(O)C=CC=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble in DMSO

Preparing Stock Solutions

The following data is based on the product molecular weight 374.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.67 mL 13.36 mL 26.71 mL
5 mM 0.53 mL 2.67 mL 5.34 mL
10 mM 0.27 mL 1.34 mL 2.67 mL
50 mM 0.05 mL 0.27 mL 0.53 mL

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Product Datasheets

Certificate of Analysis is currently unavailable
on-line. Please contact Customer Service
Safety Datasheet

References

References are publications that support the products' biological activity.

Birch et al (1988) Studies in the guinea-pig with ICI 185,282: a thromboxane A2 receptor antagonist. J.Pharm.Pharmacol. 40 706 PMID: 2907537


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Keywords: ICI 185,282, supplier, Potent, thromboxane, A2, TXA2, receptors, antagonists, TP, Prostanoid, prostaglandins, prostacyclins, eicosanoids, ICI185282, AstraZeneca, Prostanoid, Receptors, Prostanoid, Receptors, Tocris Bioscience

1 Citation for ICI 185,282

Citations are publications that use Tocris products. Selected citations for ICI 185,282 include:

Kleinbongard et al (2011) Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation. Circ Res 108 344 PMID: 21183739


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