Discontinued ProductICI 185,282 (Cat. No. 0836) has been withdrawn from sale for commercial reasons.
Potent thromboxane receptor antagonist.
Sold with the permission of AstraZeneca UK Ltd.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Birch et al (1988) Studies in the guinea-pig with ICI 185,282: a thromboxane A2 receptor antagonist. J.Pharm.Pharmacol. 40 706 PMID: 2907537
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Keywords: ICI 185,282, ICI 185,282 supplier, Potent, thromboxane, A2, TXA2, receptors, antagonists, TP, Prostanoid, prostaglandins, prostacyclins, eicosanoids, ICI185282, AstraZeneca, Receptors, 0836, Tocris Bioscience
1 Citation for ICI 185,282
Citations are publications that use Tocris products. Selected citations for ICI 185,282 include:
Kleinbongard et al (2011) Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation. Circ Res 108 344 PMID: 21183739
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.