ICI 185,282

Discontinued Product

ICI 185,282 (Cat. No. 0836) has been withdrawn from sale for commercial reasons.
Cat.No. 0836 - ICI 185,282 | C18H21F3O5 | CAS No. 106393-80-0
Description: Potent thromboxane receptor antagonist
Chemical Name: 5-(Z)-7-(4-o-Hydroxyphenyl-2-trifluoromethyl-1,3 dioxan-cis-5-yl)heptenoic acid
Datasheet
Citations (1)
Reviews
Literature

Biological Activity

Potent thromboxane receptor antagonist.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 374.36
Formula C18H21F3O5
Storage Desiccate at -20°C
CAS Number 106393-80-0
PubChem ID 5311390
InChI Key ZWAVGFSZMACJHA-PMNBYGLBSA-N
Smiles OC(=O)CCC\C=C/C[C@@H]1CO[C@@H](O[C@@H]1C1=C(O)C=CC=C1)C(F)(F)F

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

Certificate of Analysis is currently unavailable on-line.
Please contact Customer Service

References

References are publications that support the biological activity of the product.

Birch et al (1988) Studies in the guinea-pig with ICI 185,282: a thromboxane A2 receptor antagonist. J.Pharm.Pharmacol. 40 706 PMID: 2907537

View Related Products by Target

View Related Products by Product Action

View all Prostanoid Receptor Antagonists

Keywords: ICI 185,282, ICI 185,282 supplier, Potent, thromboxane, A2, TXA2, receptors, antagonists, TP, Prostanoid, prostaglandins, prostacyclins, eicosanoids, ICI185282, AstraZeneca, Receptors, 0836, Tocris Bioscience

1 Citation for ICI 185,282

Citations are publications that use Tocris products. Selected citations for ICI 185,282 include:

Kleinbongard et al (2011) Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation. Circ Res 108 344 PMID: 21183739


Reviews for ICI 185,282

There are currently no reviews for this product. Be the first to review ICI 185,282 and earn rewards!

Have you used ICI 185,282?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Cardiovascular

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Immunology

Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Asthma

Asthma Poster

Asthma is one of the most common chronic diseases in the world, affecting over 300 million people. This poster highlights key pathways and new therapies used to treat the condition, including those currently in clinical development.

Cardiovascular

Cardiovascular Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Pain

Pain Poster

Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.