Ibotenic acid

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Cat.No. 0285 - Ibotenic acid | C5H6N2O4 | CAS No. 2552-55-8
Description: Non-selective NMDA agonist
Chemical Name: α-Amino-(3-hydroxy-5-isoxazolyl)acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (3)
Literature

Biological Activity

NMDA and metabotropic glutamate receptor agonist.

Technical Data

M. Wt 158.11
Formula C5H6N2O4
Storage Desiccate at -20°C
Purity ≥98% (HPLC)
CAS Number 2552-55-8
PubChem ID 1233
InChI Key IRJCBFDCFXCWGO-UHFFFAOYSA-N
Smiles NC(C(O)=O)C1=CC(O)=NO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
1.1eq. NaOH 15.81 100
water 1.58 10

Preparing Stock Solutions

The following data is based on the product molecular weight 158.11. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.32 mL 31.62 mL 63.25 mL
5 mM 1.26 mL 6.32 mL 12.65 mL
10 mM 0.63 mL 3.16 mL 6.32 mL
50 mM 0.13 mL 0.63 mL 1.26 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Johnston et al (1968) Central actions of ibotenic acid and muscimol. Biochem.Pharmacol. 17 2488 PMID: 5752907

Nakanishi (1992) Molecular diversity of glutamate receptors and implications for brain functions. Science 258 597 PMID: 1329206

Pin and Duvoisin (1995) The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34 1 PMID: 7623957

Watkins and Evans (1981) Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 21 165 PMID: 6112965


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Keywords: Ibotenic acid, supplier, Non-Selective, NMDA, agonists, mGlur, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Metabotropic, NMDA, Receptors, Tocris Bioscience

3 Citations for Ibotenic acid

Citations are publications that use Tocris products. Selected citations for Ibotenic acid include:

Pitts and Takahashi (2011) The central amygdala nucleus via corticotropin-releasing factor is necessary for time-limited consolidation processing but not storage of contextual fear memory. Neuroreport 95 86 PMID: 21093597

Renouard et al (2015) The supramammillary nucleus and the claustrum activate the cortex during REM sleep. Neurobiol Learn Mem 1 e1400177 PMID: 26601158

Karlsson et al (2013) Exaggerated cue-induced reinstatement of cocaine seeking but not incubation of cocaine craving in a developmental rat model of schizophrenia. Psychopharmacology (Berl) 226 45 PMID: 23010798


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Pathways for Ibotenic acid

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