Ibotenic acid

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Description: NMDA agonist; also non selective mGlu agonist
Chemical Name: α-Amino-(3-hydroxy-5-isoxazolyl)acetic acid
Purity: ≥98% (HPLC)
Datasheet
Citations (4)
Reviews
Literature (6)

Biological Activity for Ibotenic acid

Ibotenic acid is a NMDA and metabotropic glutamate receptor agonist.

Technical Data for Ibotenic acid

M. Wt 158.11
Formula C5H6N2O4
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2552-55-8
PubChem ID 1233
InChI Key IRJCBFDCFXCWGO-UHFFFAOYSA-N
Smiles NC(C(O)=O)C1=CC(O)=NO1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ibotenic acid

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 1.58 10
1.1eq. NaOH 15.81 100

Preparing Stock Solutions for Ibotenic acid

The following data is based on the product molecular weight 158.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 6.32 mL 31.62 mL 63.25 mL
5 mM 1.26 mL 6.32 mL 12.65 mL
10 mM 0.63 mL 3.16 mL 6.32 mL
50 mM 0.13 mL 0.63 mL 1.26 mL

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Product Datasheets for Ibotenic acid

Certificate of Analysis / Product Datasheet
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References for Ibotenic acid

References are publications that support the biological activity of the product.

Johnston et al (1968) Central actions of ibotenic acid and muscimol. Biochem.Pharmacol. 17 2488 PMID: 5752907

Nakanishi (1992) Molecular diversity of glutamate receptors and implications for brain functions. Science 258 597 PMID: 1329206

Pin and Duvoisin (1995) The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34 1 PMID: 7623957

Watkins and Evans (1981) Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 21 165 PMID: 6112965


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Keywords: Ibotenic acid, Ibotenic acid supplier, Non-Selective, NMDA, agonists, mGlur, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Metabotropic, Non-selective, mGlu, 0285, Tocris Bioscience

4 Citations for Ibotenic acid

Citations are publications that use Tocris products. Selected citations for Ibotenic acid include:

Joseph et al (2018) Role of Prefrontal Cortex Anti- and Pro-inflammatory Cytokines in the Development of Abnormal Behaviors Induced by Disconnection of the Ventral Hippocampus in Neonate Rats. Front Behav Neurosci 12 244 PMID: 30459571

Karlsson et al (2013) Exaggerated cue-induced reinstatement of cocaine seeking but not incubation of cocaine craving in a developmental rat model of schizophrenia. Psychopharmacology (Berl) 226 45 PMID: 23010798

Pitts and Takahashi (2011) The central amygdala nucleus via corticotropin-releasing factor is necessary for time-limited consolidation processing but not storage of contextual fear memory. Neuroreport 95 86 PMID: 21093597

Renouard et al (2015) The supramammillary nucleus and the claustrum activate the cortex during REM sleep. Neurobiol Learn Mem 1 e1400177 PMID: 26601158


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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