HU 210

Pricing Availability Delivery Time Qty
Cat.No. 0966 - HU 210 | C25H38O3 | CAS No. 112830-95-2
Description: Highly potent cannabinoid receptor agonist
Chemical Name: (6aR)-trans-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol
Purity: ≥98% (HPLC)
Datasheet
Citations (16)
Literature

Biological Activity

A highly potent cannabinoid receptor agonist (Ki values are 0.061 and 0.52 nM at cloned human CB1 and CB2 receptors respectively). Induces spatial memory deficits and suppresses hippocampal firing rates in rats. Also displays agonist activity at GPR55 (EC50 = 26 nM).

Technical Data

M. Wt 386.57
Formula C25H38O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 112830-95-2
PubChem ID 9821569
InChI Key SSQJFGMEZBFMNV-WOJBJXKFSA-N
Smiles CCCCCCC(C)(C)C1=CC(O)=C([C@@]2([H])[C@@](C(C)(C)O3)([H])CC=C(CO)C2)C3=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 38.66 100
ethanol 38.66 100

Preparing Stock Solutions

The following data is based on the product molecular weight 386.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.59 mL 12.93 mL 25.87 mL
5 mM 0.52 mL 2.59 mL 5.17 mL
10 mM 0.26 mL 1.29 mL 2.59 mL
50 mM 0.05 mL 0.26 mL 0.52 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Howlett et al (1990) Stereochemical effects of 11-OH-Δ8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor. Neuropharmacology 29 161 PMID: 2158635

Mechoulam et al (1988) Enantiomeric cannabinoids: stereospecificity of psychotropic activity. Experientia 44 762 PMID: 3416993

Robinson et al (2007) The synthetic cannabinoid HU210 reduces spatial memory deficits and suppresses hippocampal firing rates in rats. Br.J.Pharmacol. 151 688 PMID: 17502849

Ryberg et al (2007) The orphan receptor GPR55 is a novel cannabinoid receptor. Br.J.Pharmacol. 152 1092 PMID: 17876302


If you know of a relevant reference for HU 210, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Non-selective Cannabinoid Agonists

Keywords: potent cannabinoids agonists Non-Selective Receptors HU210 cb2r cb1r Non-selective Cannabinoids

16 Citations for HU 210

Citations are publications that use Tocris products. Selected citations for HU 210 include:

Trazzi et al (2010) CB1 cannabinoid receptors increase neuronal precursor proliferation through AKT/glycogen synthase kinase-3β/β-catenin signaling. Br J Pharmacol 285 10098 PMID: 20083607

Rajesh et al (2010) Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells. Br J Pharmacol 160 688 PMID: 20590572

Mason and Cheer (2009) Cannabinoid receptor activation reverses kainate-induced synchronized population burst firing in rat hippocampus. Front Integr Neurosci 3 13 PMID: 19562087

Mukhopadhyay et al (2007) Pharmacological inhibition of CB1 cannabinoid receptor protects against doxorubicin-induced cardiotoxicity. J Am Coll Cardiol 50 528 PMID: 17678736

Czesnik et al (2007) Cannabinoid action in the olfactory epithelium. Proc Natl Acad Sci U S A 104 2967 PMID: 17301239

Jayamanne et al (2006) Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models. J Biol Chem 147 281 PMID: 16331291

Graham et al (2006) Induction of Krox-24 by endogenous cannabinoid type 1 receptors in Neuro2A cells is mediated by the MEK-ERK MAPK pathway and is suppressed by the phosphatidylinositol 3-kinase pathway. J Biol Chem 281 29085 PMID: 16864584

Savinainen et al (2005) Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor. Br J Pharmacol 145 636 PMID: 15852035

Savinainen et al (2003) An optimized approach to study endocannabinoid signaling: evidence against constitutive activity of rat brain adenosine A1 and cannabinoid CB1 receptors. Br J Pharmacol 140 1451 PMID: 14623770

Adami et al (2002) Gastric antisecretory role and immunohistochemical localization of cannabinoid receptors in the rat stomach. Br J Pharmacol 135 1598 PMID: 11934799

Martin et al (2000) Effects of cannabinoid receptor agonists on neuronally-evoked contractions of urinary bladder tissues isolated from rat, mouse, pig, dog, monkey and human. Br J Pharmacol 129 1707 PMID: 10780977

Zimmer et al (1999) Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. J Biol Chem 96 5780 PMID: 10318961

Chataigneau et al (1998) Cannabinoid CB1 receptor and endothelium-dependent hyperpolarization in guinea-pig carotid, rat mesenteric and porcine coronary arteries. Proc Natl Acad Sci U S A 123 968 PMID: 9535027

Cao et al (2013) Cannabinoid HU210 protects isolated rat stomach against impairment caused by serum of rats with experimental acute pancreatitis. PLoS One 7 e52921 PMID: 23285225

Lim et al (2013) Ghrelin and cannabinoids require the ghrelin receptor to affect cellular energy metabolism. Br J Pharmacol 365 303 PMID: 23178796

Butti et al (2012) Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity. Brain 135 3320 PMID: 23008234


Do you know of a great paper that uses HU 210 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
Neurodegeneration

Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
Pain

Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
Cannabinoid Receptor Ligands

Cannabinoid Receptor Ligands Scientific Review

Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.

Pathways for HU 210

Protocols

TODO: Add Protocols