Discontinued Product

HNGF6A (Cat. No. 5154) has been withdrawn from sale for commercial reasons.
Description: Humanin analog; increases insulin sensitivity
Citations (1)
Literature (2)
Pathways (1)

Biological Activity for HNGF6A

HNGF6A is a humanin analog; increases glucose stimulated insulin secretion and glucose metabolism in vivo and in vitro. Also enhances glucose sensing in βTC3 cells and lowers blood glucose in Zucker diabetic fatty rats. Prevents endothelial dysfunction and delays progression of atherosclerosis in vivo. Protects neurons from NMDA-induced toxicity.

Technical Data for HNGF6A

M. Wt 2581.13
Formula C112H198N34O31S2
Storage Store at -20°C
CAS Number 1093111-54-6
PubChem ID 90489015
Smiles [H]N[C@@H](CCSC)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for HNGF6A

References are publications that support the biological activity of the product.

Kuliawat et al (2013) Potent humanin analog increases glucose-stimulated Ins secretion through enhanced metabolism in the β cell. FASEB J. 27 4890 PMID: 23995290

Muzumdar et al (2009) Humanin: a novel central regulator of peripheral Ins action. PLoS One. 4 e6334 PMID: 19623253

Oh et al (2011) Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice. Atherosclerosis. 219 65 PMID: 21763658

Alam et al (2018) A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-induced neurotoxicity. ACS Chem.Neurosci. 9 462 PMID: 29161500

Keywords: HNGF6A, HNGF6A supplier, Alzheimer's, disease, insulin, diabetes, β, cells, humanin, endothelial, dysfunction, atherosclerosis, analogue, HN, beta, analog, Insulin, and, Insulin-like, Receptors, insulin-like, 5154, Tocris Bioscience

1 Citation for HNGF6A

Citations are publications that use Tocris products. Selected citations for HNGF6A include:

Alam et al (2018) A small molecule mimetic of the humanin peptide as a candidate for modulating NMDA-induced neurotoxicity. ACS Chem.Neurosci. 9 462 PMID: 29161500

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Peptides Involved in Appetite Modulation Scientific Review

Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.

Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Pathways for HNGF6A

Insulin Signaling Pathway

Insulin Signaling Pathway

Signaling through the insulin pathway is fundamental for the regulation of intracellular glucose levels. This pathway can become dysregulated in diabetes.