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Potent and selective cFMS kinase inhibitor (IC50 = 0.06 μM). Exhibits selectivity for cFMS kinase over 186 other kinases. Inhibits CSF-1-induced growth of rat monocytes in vitro. Also inhibits bone resorption in osteoclast cultures, as well as connective tissue and bone destruction in a rat adjuvant arthritis model. Suppresses M-NFS-60 tumor cell growth in mice. Orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 366.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.46 mL||27.29 mL||54.58 mL|
|2.5 mM||1.09 mL||5.46 mL||10.92 mL|
|5 mM||0.55 mL||2.73 mL||5.46 mL|
|25 mM||0.11 mL||0.55 mL||1.09 mL|
References are publications that support the biological activity of the product.
Conway et al (2005) Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc.Natl.Acad.Sci.U.S.A. 102 16078 PMID: 16249345
Conway et al (2008) Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats. J.Pharmacol.Exp.Ther. 326 41 PMID: 18434589
If you know of a relevant reference for GW 2580, please let us know.
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Keywords: GW 2580, GW 2580 supplier, GW2580, cFMS, kinase, inhibitors, inhibits, CSF-1, colony-stimulating, factor, osteoclasts, arthritis, selective, orally, bioavailable, Other, RTKs, 5673, Tocris Bioscience
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