You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for GW 2580
GW 2580 is a potent and selective cFMS kinase inhibitor (IC50 = 0.06 μM). Exhibits selectivity for cFMS kinase over 186 other kinases. Inhibits CSF-1-induced growth of rat monocytes in vitro. Also inhibits bone resorption in osteoclast cultures, as well as connective tissue and bone destruction in a rat adjuvant arthritis model. Suppresses M-NFS-60 tumor cell growth in mice. Orally bioavailable.
Technical Data for GW 2580
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GW 2580
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for GW 2580
The following data is based on the product molecular weight 366.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||5.46 mL||27.29 mL||54.58 mL|
|2.5 mM||1.09 mL||5.46 mL||10.92 mL|
|5 mM||0.55 mL||2.73 mL||5.46 mL|
|25 mM||0.11 mL||0.55 mL||1.09 mL|
References for GW 2580
References are publications that support the biological activity of the product.
Conway et al (2005) Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc.Natl.Acad.Sci.U.S.A. 102 16078 PMID: 16249345
Conway et al (2008) Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats. J.Pharmacol.Exp.Ther. 326 41 PMID: 18434589
If you know of a relevant reference for GW 2580, please let us know.
View Related Products by Product Action
Keywords: GW 2580, GW 2580 supplier, GW2580, cFMS, kinase, inhibitors, inhibits, CSF-1, colony-stimulating, factor, osteoclasts, arthritis, selective, orally, bioavailable, Other, RTKs, 5673, Tocris Bioscience
Citations for GW 2580
Citations are publications that use Tocris products.
Currently there are no citations for GW 2580. Do you know of a great paper that uses GW 2580 from Tocris? Please let us know.
Reviews for GW 2580
There are currently no reviews for this product. Be the first to review GW 2580 and earn rewards!
Have you used GW 2580?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.