GW 2580

Pricing Availability   Qty
Cat.No. 5673 - GW 2580 | C20H22N4O3 | CAS No. 870483-87-7
Description: Selective cFMS kinase inhibitor; orally bioavailable
Chemical Name: 5-[[3-Methoxy-4-[(4-methoxyphenyl)methoxy]phenyl]methyl]-2,4-pyrimidinediamine
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Potent and selective cFMS kinase inhibitor (IC50 = 0.06 μM). Exhibits selectivity for cFMS kinase over 186 other kinases. Inhibits CSF-1-induced growth of rat monocytes in vitro. Also inhibits bone resorption in osteoclast cultures, as well as connective tissue and bone destruction in a rat adjuvant arthritis model. Suppresses M-NFS-60 tumor cell growth in mice. Orally bioavailable.

Technical Data

M. Wt 366.41
Formula C20H22N4O3
Storage Store at -20°C
Purity ≥99% (HPLC)
CAS Number 870483-87-7
PubChem ID 11617559
InChI Key MYQAUKPBNJWPIE-UHFFFAOYSA-N
Smiles NC1=C(CC2=CC(OC)=C(OCC3=CC=C(OC)C=C3)C=C2)C=NC(N)=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 18.32 50

Preparing Stock Solutions

The following data is based on the product molecular weight 366.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.5 mM 5.46 mL 27.29 mL 54.58 mL
2.5 mM 1.09 mL 5.46 mL 10.92 mL
5 mM 0.55 mL 2.73 mL 5.46 mL
25 mM 0.11 mL 0.55 mL 1.09 mL

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References

References are publications that support the biological activity of the product.

Conway et al (2005) Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc.Natl.Acad.Sci.U.S.A. 102 16078 PMID: 16249345

Conway et al (2008) Effects of the cFMS kinase inhibitor 5-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)pyrimidine-2,4-diamine (GW2580) in normal and arthritic rats. J.Pharmacol.Exp.Ther. 326 41 PMID: 18434589


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