GTP 14564

Discontinued Product

GTP 14564 (Cat. No. 2086) has been withdrawn from sale for commercial reasons.
Description: Class III receptor tyrosine kinase (RTK) inhibitor
Chemical Name: 3-Phenyl-1H-benzofuro[3,2-c]pyrazole
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for GTP 14564

GTP 14564 is a potent, selective inhibitor of class III receptor tyrosine kinases (IC50 values are 0.3 μM for c-Fms, c-Kit, FLT3 and ITD-FLT3 and 1 μM for PDGFRβ). Displays no activity against ERK1, ERK2, EGFR, MEK1, HER2, Src, Abl, PKC, PKA and Akt (IC50 > 10 μM). Inhibits FL-dependent proliferation in BaF/ITD-FLT3 cells more potently than BaF/wt-FLT3 cells; anti-leukemic.

Technical Data for GTP 14564

M. Wt 234.26
Formula C15H10N2O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 34823-86-4
PubChem ID 3385203
Smiles N1N=C(C2=C1C1=C(O2)C=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Keywords: GTP 14564, GTP 14564 supplier, Class, III, receptor, tyrosine, kinase, RTKs, inhibitors, inhibits, Receptors, GTP14564, Other, 2086, Tocris Bioscience

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