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Potent, selective inhibitor of class III receptor tyrosine kinases (IC50 values are 0.3 μM for c-Fms, c-Kit, FLT3 and ITD-FLT3 and 1 μM for PDGFRβ). Displays no activity against ERK1, ERK2, EGFR, MEK1, HER2, Src, Abl, PKC, PKA and Akt (IC50 > 10 μM). Inhibits FL-dependent proliferation in BaF/ITD-FLT3 cells more potently than BaF/wt-FLT3 cells; anti-leukemic.
|Storage||Store at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 234.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||4.27 mL||21.34 mL||42.69 mL|
|5 mM||0.85 mL||4.27 mL||8.54 mL|
|10 mM||0.43 mL||2.13 mL||4.27 mL|
|50 mM||0.09 mL||0.43 mL||0.85 mL|
References are publications that support the biological activity of the product.
Murata et al (2003) Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J.Biol.Chem. 278 32892 PMID: 12815052
Yao et al (2005) Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: the key role of the STAT5 signal transduction pathway. Leukemia 19 1605 PMID: 16034464
If you know of a relevant reference for GTP 14564, please let us know.
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Keywords: GTP 14564, GTP 14564 supplier, Class, III, receptor, tyrosine, kinase, RTKs, inhibitors, inhibits, Receptors, GTP14564, Other, 2086, Tocris Bioscience
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