GTP 14564

Pricing Availability Delivery Time Qty
Cat.No. 2086 - GTP 14564 | C15H10N2O | CAS No. 34823-86-4
Description: Class III receptor tyrosine kinase (RTK) inhibitor
Chemical Name: 3-Phenyl-1H-benzofuro[3,2-c]pyrazole
Purity: ≥99% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent, selective inhibitor of class III receptor tyrosine kinases (IC50 values are 0.3 μM for c-Fms, c-Kit, FLT3 and ITD-FLT3 and 1 μM for PDGFRβ). Displays no activity against ERK1, ERK2, EGFR, MEK1, HER2, Src, Abl, PKC, PKA and Akt (IC50 > 10 μM). Inhibits FL-dependent proliferation in BaF/ITD-FLT3 cells more potently than BaF/wt-FLT3 cells; anti-leukemic.

Compound Libraries

GTP 14564 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 234.26
Formula C15H10N2O
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 34823-86-4
PubChem ID 3385203
InChI Key DZQLVVLATXPWBK-UHFFFAOYSA-N
Smiles N1N=C(C2=C1C1=C(O2)C=CC=C1)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.43 100
ethanol 5.86 25

Preparing Stock Solutions

The following data is based on the product molecular weight 234.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.27 mL 21.34 mL 42.69 mL
5 mM 0.85 mL 4.27 mL 8.54 mL
10 mM 0.43 mL 2.13 mL 4.27 mL
50 mM 0.09 mL 0.43 mL 0.85 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Murata et al (2003) Selective cytotoxic mechanism of GTP-14564, a novel tyrosine kinase inhibitor in leukemia cells expressing a constitutively active Fms-like tyrosine kinase 3 (FLT3). J.Biol.Chem. 278 32892 PMID: 12815052

Yao et al (2005) Human leukemias with mutated FLT3 kinase are synergistically sensitive to FLT3 and Hsp90 inhibitors: the key role of the STAT5 signal transduction pathway. Leukemia 19 1605 PMID: 16034464


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Keywords: GTP 14564, supplier, Class, III, receptor, tyrosine, kinase, RTKs, inhibitors, inhibits, Receptors, GTP14564, Other, RTKs, Other, RTKs, Tocris Bioscience

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