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Submit ReviewGrifolic acid
Description: Selective partial FFA4 (GPR120) agonist
Chemical Name: 2,4-Dihydroxy-6-methyl-3-[(2E,6E)-3,7,11-trimethyl-2,6,10-dodecatrien-1-yl]-benzoic acid
Purity: ≥98% (HPLC)
Biological Activity for Grifolic acid
Grifolic acid is a selective partial FFA4 (GPR120) agonist. Induces ERK and [Ca2+]i responses in cells expressing GPR120, but not those expressing GPR40.
Technical Data for Grifolic acid
| M. Wt | 372.5 |
| Formula | C23H32O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 80557-12-6 |
| PubChem ID | 9976563 |
| InChI Key | QPIZDZGIXDKCRC-JTCWOHKRSA-N |
| Smiles | OC1=C(C/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)C(O)=C(C(O)=O)C(C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Grifolic acid
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.25 | 100 |
Preparing Stock Solutions for Grifolic acid
The following data is based on the product molecular weight 372.5. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.68 mL | 13.42 mL | 26.85 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.37 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.68 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
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Product Datasheets for Grifolic acid
References for Grifolic acid
References are publications that support the biological activity of the product.
Hara et al (2009) Novel selective ligands for free fatty acid receptors GPR120 and GPR40. Naunyn Schmiedebergs Arch.Pharmacol. 380 247 PMID: 19471906
Sun et al (2010) Structure-activity relationships of GPR120 agonists based on a docking simulation. Mol.Pharmacol. 78 804 PMID: 20685848
If you know of a relevant reference for Grifolic acid, please let us know.
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Keywords: Grifolic acid, Grifolic acid supplier, G, protein-coupled, receptors, GPR120, orphan, selective, partial, agonists, FFA4, free, fatty, acid, Free, Fatty, Acid, Receptors, 4581, Tocris Bioscience
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