GR 32191 hydrochloride

Discontinued Product

Unfortunately GR 32191 hydrochloride (Cat. No. 1958) has been withdrawn from sale for commercial reasons.
Cat.No. 1958 - GR 32191 hydrochloride | C30H39NO4.HCl | CAS No. 85505-64-2
Description: Potent thromboxane A2/TP receptor antagonist
Alternative Names: Vapiprost
Chemical Name: (4Z)-7-[(1R,2R,3S,5S)-5-([1,1'-Biphenyl]-4-ylmethoxy)-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-heptenoic acid hydrochloride
Purity: ≥98% (HPLC)

Biological Activity

Potent thromboxane A2 (TP) receptor antagonist. Inhibits platelet aggregation (pA2 ~ 8.3) and relaxes vascular and airway smooth muscle (pA2 = 7.9 - 10.3).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data

M. Wt 514.1
Formula C30H39NO4.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 85505-64-2
Smiles Cl[H].O[C@H]1C[C@H](OCC2=CC=C(C=C2)C2=CC=CC=C2)[C@H](CC\C=C/CCC(O)=O)[C@H]1N1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 514.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.95 mL 9.73 mL 19.45 mL
5 mM 0.39 mL 1.95 mL 3.89 mL
10 mM 0.19 mL 0.97 mL 1.95 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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Product Datasheets

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References are publications that support the products' biological activity.

Lumley et al (1989) GR32191, a highly potent and specific thromboxane A2 receptor blocking drug on platelets and vascular and airways smooth muscle in vitro. Br.J.Pharmacol. 97 783 PMID: 2527074

Ogletree and Allen (1992) Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J.Pharmacol.Exp.Ther. 260 789 PMID: 1531361

Takahara et al (1990) The response to thromboxane A2 analogues in human platelets. J.Biol.Chem. 265 6836 PMID: 2139029

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