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Potent thromboxane A2 (TP) receptor antagonist. Inhibits platelet aggregation (pA2 ~ 8.3) and relaxes vascular and airway smooth muscle (pA2 = 7.9 - 10.3).
Sold for research purposes under agreement from GlaxoSmithKline
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Lumley et al (1989) GR32191, a highly potent and specific thromboxane A2 receptor blocking drug on platelets and vascular and airways smooth muscle in vitro. Br.J.Pharmacol. 97 783 PMID: 2527074
Ogletree and Allen (1992) Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J.Pharmacol.Exp.Ther. 260 789 PMID: 1531361
Takahara et al (1990) The response to thromboxane A2 analogues in human platelets. J.Biol.Chem. 265 6836 PMID: 2139029
Keywords: GR 32191 hydrochloride, GR 32191 hydrochloride supplier, Potent, thromboxane, A2/TP, receptor, antagonists, TP, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, GR32191, hydrochloride, GlaxoSmithKline, GSK, Vapiprost, Receptors, 1958, Tocris Bioscience
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.