GR 32191 hydrochloride

Discontinued Product

GR 32191 hydrochloride (Cat. No. 1958) has been withdrawn from sale for commercial reasons.
Description: Potent thromboxane A2/TP receptor antagonist
Alternative Names: Vapiprost
Chemical Name: (4Z)-7-[(1R,2R,3S,5S)-5-([1,1'-Biphenyl]-4-ylmethoxy)-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-heptenoic acid hydrochloride
Purity: ≥98% (HPLC)

Biological Activity for GR 32191 hydrochloride

Potent thromboxane A2 (TP) receptor antagonist. Inhibits platelet aggregation (pA2 ~ 8.3) and relaxes vascular and airway smooth muscle (pA2 = 7.9 - 10.3).

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Technical Data for GR 32191 hydrochloride

M. Wt 514.1
Formula C30H39NO4.HCl
Storage Desiccate at +4°C
Purity ≥98% (HPLC)
CAS Number 85505-64-2
Smiles Cl[H].O[C@H]1C[C@H](OCC2=CC=C(C=C2)C2=CC=CC=C2)[C@H](CC\C=C/CCC(O)=O)[C@H]1N1CCCCC1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for GR 32191 hydrochloride

References for GR 32191 hydrochloride

References are publications that support the biological activity of the product.

Lumley et al (1989) GR32191, a highly potent and specific thromboxane A2 receptor blocking drug on platelets and vascular and airways smooth muscle in vitro. Br.J.Pharmacol. 97 783 PMID: 2527074

Ogletree and Allen (1992) Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J.Pharmacol.Exp.Ther. 260 789 PMID: 1531361

Takahara et al (1990) The response to thromboxane A2 analogues in human platelets. J.Biol.Chem. 265 6836 PMID: 2139029

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Citations for GR 32191 hydrochloride

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