GR 32191 hydrochloride
Discontinued ProductUnfortunately GR 32191 hydrochloride (Cat. No. 1958) has been withdrawn from sale for commercial reasons.
Potent thromboxane A2 (TP) receptor antagonist. Inhibits platelet aggregation (pA2 ~ 8.3) and relaxes vascular and airway smooth muscle (pA2 = 7.9 - 10.3).
Sold for research purposes under agreement from GlaxoSmithKline
|Storage||Desiccate at +4°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 514.1. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.95 mL||9.73 mL||19.45 mL|
|5 mM||0.39 mL||1.95 mL||3.89 mL|
|10 mM||0.19 mL||0.97 mL||1.95 mL|
|50 mM||0.04 mL||0.19 mL||0.39 mL|
References are publications that support the products' biological activity.
Lumley et al (1989) GR32191, a highly potent and specific thromboxane A2 receptor blocking drug on platelets and vascular and airways smooth muscle in vitro. Br.J.Pharmacol. 97 783 PMID: 2527074
Ogletree and Allen (1992) Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J.Pharmacol.Exp.Ther. 260 789 PMID: 1531361
Takahara et al (1990) The response to thromboxane A2 analogues in human platelets. J.Biol.Chem. 265 6836 PMID: 2139029
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Keywords: GR 32191 hydrochloride, supplier, Potent, thromboxane, A2/TP, receptor, antagonists, TP, TXA2, Prostanoid, prostaglandins, prostacyclins, eicosanoids, GR32191, hydrochloride, GlaxoSmithKline, GSK, Vapiprost, Prostanoid, Receptors, Prostanoid, Receptors, Tocris Bioscience
Citations for GR 32191 hydrochloride
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Literature in this Area
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Peripheral sensitization is the reduction in the threshold of excitability of sensory neurons that results in an augmented response to a given external stimulus. This poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described.