GR 135531

Pricing Availability Delivery Time Qty
Cat.No. 0896 - GR 135531 | C14H17N3O3 | CAS No. 190277-13-5
Description: High affinity melatonin MT3 ligand
Alternative Names: 5-MCA-NAT
Chemical Name: 5-Methoxycarbonylamino-N-acetyltryptamine
Purity: ≥97% (HPLC)
Datasheet
Citations (5)
Literature

Biological Activity

Binds with high affinity to MT3 melatonin sites in hamster brain, and low affinity (and no efficacy) at MT1 and MT2 melatonin receptors and thus can be used to discriminate between the melatonin receptor subtypes.

Technical Data

M. Wt 275.31
Formula C14H17N3O3
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 190277-13-5
PubChem ID 4284525
InChI Key MPZVHKLZCUEJFO-UHFFFAOYSA-N
Smiles COC(=O)NC1=CC=C2NC=C(CCNC(C)=O)C2=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in ethanol

Preparing Stock Solutions

The following data is based on the product molecular weight 275.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.63 mL 18.16 mL 36.32 mL
5 mM 0.73 mL 3.63 mL 7.26 mL
10 mM 0.36 mL 1.82 mL 3.63 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References

References are publications that support the products' biological activity.

Dubocovich (1995) Melatonin receptors: are there multiple subtypes? TiPS 16 50 PMID: 7762083

Lucchelli et al (1997) Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT4 and melatonin receptors. Br.J.Pharmacol. 121 1775 PMID: 9283717


If you know of a relevant reference for GR 135531, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Melatonin Receptor Ligands

Keywords: High affinity melatonin MT3 ligands Receptors GR135531 5MCANAT 5-MCA-NAT Melatonin (MT) Receptors

5 Citations for GR 135531

Citations are publications that use Tocris products. Selected citations for GR 135531 include:

Loma et al (2015) Diadenosine tetraphosphate induces tight junction disassembly thus increasing corneal epithelial permeability. J Neurosci 172 1045 PMID: 25297531

Crooke et al (2013) Melatonin and its analog 5-methoxycarbonylamino-N-acetyltryptamine potentiate adrenergic receptor-mediated ocular hypotensive effects in rabbits: significance for combination therapy in glaucoma. J Pharmacol Exp Ther 346 138 PMID: 23591996

Kojima et al (2011) Melatonin inhibits tachykinin NK2 receptor-triggered 5-HT release from guinea pig isolated colonic mucosa. Br J Pharmacol 162 1179 PMID: 21091649

Tunstall et al (2011) MT2 receptors mediate the inhibitory effects of melatonin on nitric oxide-induced relaxation of porcine isolated coronary arteries. Br J Pharmacol 336 127 PMID: 20959363

Sjöblom et al (2001) Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion. J Pharmacol Exp Ther 108 625 PMID: 11518737


Do you know of a great paper that uses GR 135531 from Tocris? If so please let us know.

Commented out for usability testing

Reviews

TODO: Add Reviews

Literature in this Area

GPCR

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling

Pathways for GR 135531

Protocols

TODO: Add Protocols