GPR52 Comp-43

Pricing Availability   Qty
Description: GPR52 receptor antagonist
Chemical Name: (2E)-5-Phenyl-1-(2-thienyl)-2-penten-1-one
Purity: ≥98% (HPLC)

Biological Activity for GPR52 Comp-43

GPR52 Comp-43 is a GPR52 receptor antagonist (IC50 = 0.63 μM). The use of GPR52 Comp-43 in animal models of Huntington's Disease leads to degradation and reduction of soluble and aggregated mutant huntingtin protein in the striatum. It also reduces neuronal loss, promotes neuronal survival and improves motor functions in vivo. GPR52 Comp-43 is active in vitro and brain penetrant.

Technical Data for GPR52 Comp-43

M. Wt 242.34
Formula C15H14OS
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1239987-91-7
PubChem ID 156588927
Smiles O=C(C1=CC=CS1)/C=C/CCC2=CC=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for GPR52 Comp-43

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 24.23 100
ethanol 24.23 100

Preparing Stock Solutions for GPR52 Comp-43

The following data is based on the product molecular weight 242.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.13 mL 20.63 mL 41.26 mL
5 mM 0.83 mL 4.13 mL 8.25 mL
10 mM 0.41 mL 2.06 mL 4.13 mL
50 mM 0.08 mL 0.41 mL 0.83 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Product Datasheets for GPR52 Comp-43

References for GPR52 Comp-43

References are publications that support the biological activity of the product.

Wang et al (2021) GPR52 antagonist reduces huntingtin levels and ameliorates Huntington's disease-related phenotypes. J.Med.Chem. 64 941 PMID: 33185430

Komatsu (2021) Discovery of the first druggable GPR52 antagonist to treat Huntington's disease. J.Med.Chem. 64 938 PMID: 33443413

If you know of a relevant reference for GPR52 Comp-43, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Orphan 7-TM Receptor Antagonists

Keywords: GPR52 Comp-43, GPR52 Comp-43 supplier, GPR52comp43, receptors, antagonists, antagonism, huntingtons, huntingtin, neuronal, GPCR, CAY10786, GPR52IN43, Orphan, 7-TM, Receptors, 7445, Tocris Bioscience

Citations for GPR52 Comp-43

Citations are publications that use Tocris products.

Currently there are no citations for GPR52 Comp-43. Do you know of a great paper that uses GPR52 Comp-43 from Tocris? Please let us know.

Reviews for GPR52 Comp-43

There are currently no reviews for this product. Be the first to review GPR52 Comp-43 and earn rewards!

Have you used GPR52 Comp-43?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review