GPi 688

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Cat.No. 3967 - GPi 688 | C19H18ClN3O4S | CAS No. 918902-32-6
Description: Allosteric glycogen phosphorylase inhibitor
Chemical Name: 2-Chloro-N-[1-[(2R)-2,3-dihydroxypropyl]-1,2,3,4-tetrahydro-2-oxo-3-quinolinyl]-6H-thieno[2,3-b]pyrrole-5-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity

Allosteric glycogen phosphorylase inhibitor; acts at the indole site of glycogen phosphorylase. Inhibits glucagon-mediated hyperglycemia in vivo in the rat.

Licensing Information

Sold with the permission of AstraZeneca UK Ltd.

Technical Data

M. Wt 419.88
Formula C19H18ClN3O4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 918902-32-6
PubChem ID 10477191
InChI Key UICNBXVDHCBKCE-PUODRLBUSA-N
Smiles OC[C@H](O)CN(C1=CC=CC=C1CC2NC(C3=CC4=C(SC(Cl)=C4)N3)=O)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.99 100
ethanol 10.5 25

Preparing Stock Solutions

The following data is based on the product molecular weight 419.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.38 mL 11.91 mL 23.82 mL
5 mM 0.48 mL 2.38 mL 4.76 mL
10 mM 0.24 mL 1.19 mL 2.38 mL
50 mM 0.05 mL 0.24 mL 0.48 mL

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References

References are publications that support the biological activity of the product.

Freeman et al (2006) Sensitivity of glycogen phosphorylase isoforms to indole site inhibitors is markedly dependent on the activation state of the enzyme. Br.J.Pharmacol. 149 775 PMID: 17016495

Poucher et al (2007) An assessment of the in vivo efficacy of the glycogen phosphorylase inhibitor GPi688 in rat models of hyperglycaemia. Br.J.Pharmacol. 152 1239 PMID: 17934512


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