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Biological Activity for GLYX 13
GLYX 13 is a NMDA receptor partial agonist that acts at the glycine site. Simultaneously acts as a promoter of the induction of long-term potentiation (LTP) and as a suppressor of long-term depression (LTD). Exhibits nootropic, neuroprotective and antinociceptive activity, and enhances learning, memory and cognition in vivo. Brain penetrant.
Technical Data for GLYX 13
(Modifications: Thr-4 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GLYX 13
|Solubility||Soluble to 2 mg/ml in water|
References for GLYX 13
References are publications that support the biological activity of the product.
Moskal et al (2005) GLYX-13: A monoclonal antibody-derived peptide that acts as an N-MthD.-aspartate receptor modulator. Neuropharmacology 49 1077 PMID: 16051282
Zhang et al (2008) A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus. 55 1238 PMID: 18796308
Wood et al (2008) Antinociceptive action of GLYX-13: a N-MthD.-aspartate receptor glycine site partial agonist. Neuroreport. 19 1059 PMID: 18580579
Burgdorf et al (2009) The N-MthD.-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats. Neurobiol.Aging 32 698 PMID: 19446371
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Keywords: GLYX 13, GLYX 13 supplier, NMDA, receptor, partial, agonists, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, GLYX13, psychoplastogen, 3406, Tocris Bioscience
Citations for GLYX 13
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Literature in this Area
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