Glycine

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Cat.No. 0219 - Glycine | C2H5NO2 | CAS No. 56-40-6
Description: Endogenous potentiator, co-transmitter
Chemical Name: Aminoethanoic acid
Datasheet
Citations (2)
Literature

Biological Activity

One of the major inhibitory neurotransmitters in the mammalian CNS, predominantly active in the spinal cord and brain stem. Also acts as a modulator of excitatory amino acid transmission mediated by NMDA receptors. Also available as part of the NMDA Receptor - Glycine Site Tocriset™.

Technical Data

M. Wt 75.07
Formula C2H5NO2
Storage Store at RT
CAS Number 56-40-6
PubChem ID 750
InChI Key DHMQDGOQFOQNFH-UHFFFAOYSA-N
Smiles NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 100 mM in water

Preparing Stock Solutions

The following data is based on the product molecular weight 75.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 13.32 mL 66.6 mL 133.21 mL
5 mM 2.66 mL 13.32 mL 26.64 mL
10 mM 1.33 mL 6.66 mL 13.32 mL
50 mM 0.27 mL 1.33 mL 2.66 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Betz (1991) Glycine receptors: heterogeneous and widespread in the mammalian brain. Trends Neurosci. 14 458 PMID: 1722365

Kuhse et al (1995) The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex. Curr.Opin.Neurobiol. 5 318 PMID: 7850154

Ascher and Johnson (1989) The NMDA receptor, its channel and its modulation by glycine. The NMDA Receptor (2nd edition). Eds. G.L.Collingr 109 PMID:

Johnson and Ascher (1987) Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325 529 PMID:


If you know of a relevant reference for Glycine, please let us know.

Keywords: Endogenous glycine receptor agonists potentiator co-transmitter GlyR Glycine Receptors Glutamate NMDA N-Methyl-D-Aspartate iGluR Ionotropic NMDA Receptors

2 Citations for Glycine

Citations are publications that use Tocris products. Selected citations for Glycine include:

Kaushal and Schlichter (2008) Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. J Neurosci 28 2221 PMID: 18305255

Sivakumaran et al (2015) Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo. Front Cell Neurosci 35 8291 PMID: 26019342


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Pathways for Glycine

Protocols

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