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Submit ReviewGlycine
Description: Endogenous potentiator of NMDA receptors
Chemical Name: Aminoethanoic acid
Biological Activity for Glycine
One of the major inhibitory neurotransmitters in the mammalian CNS, predominantly active in the spinal cord and brain stem. Also acts as a modulator of excitatory amino acid transmission mediated by NMDA receptors.
Technical Data for Glycine
| M. Wt | 75.07 |
| Formula | C2H5NO2 |
| Storage | Store at RT |
| CAS Number | 56-40-6 |
| PubChem ID | 750 |
| InChI Key | DHMQDGOQFOQNFH-UHFFFAOYSA-N |
| Smiles | NCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Glycine
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions for Glycine
The following data is based on the product molecular weight 75.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 13.32 mL | 66.6 mL | 133.21 mL |
| 5 mM | 2.66 mL | 13.32 mL | 26.64 mL |
| 10 mM | 1.33 mL | 6.66 mL | 13.32 mL |
| 50 mM | 0.27 mL | 1.33 mL | 2.66 mL |
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Product Datasheets for Glycine
References for Glycine
References are publications that support the biological activity of the product.
Betz (1991) Glycine receptors: heterogeneous and widespread in the mammalian brain. Trends Neurosci. 14 458 PMID: 1722365
Kuhse et al (1995) The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex. Curr.Opin.Neurobiol. 5 318 PMID: 7850154
Ascher and Johnson (1989) The NMDA receptor, its channel and its modulation by glycine. The NMDA Receptor (2nd edition). Eds. G.L.Collingr 109
Johnson and Ascher (1987) Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325 529
If you know of a relevant reference for Glycine, please let us know.
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Keywords: Glycine, Glycine supplier, Endogenous, glycine, receptor, agonists, potentiator, co-transmitter, GlyR, Glycine, Receptors, Glutamate, NMDA, N-Methyl-D-Aspartate, iGluR, Ionotropic, 0219, Tocris Bioscience
4 Citations for Glycine
Citations are publications that use Tocris products. Selected citations for Glycine include:
Kaushal and Schlichter (2008) Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. J Neurosci 28 2221 PMID: 18305255
Hangen et al (2018) Neuronal Activity and Intracellular Calcium Levels Regulate Intracellular Transport of Newly Synthesized AMPAR. Cell Rep 24 1001 PMID: 30044968
Kenny et al (2009) The integrity of the glycine co-agonist binding site of N-MthD.-aspartate receptors is a functional quality control checkpoint for cell surface delivery. J Biol Chem 284 324 PMID: 18990687
Sivakumaran et al (2015) Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo. Front Cell Neurosci 35 8291 PMID: 26019342
Do you know of a great paper that uses Glycine from Tocris? Please let us know.
Reviews for Glycine
Average Rating: 5 (Based on 1 Review.)
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Use of glycine as NMDA receptor co-agonist.
By
Anonymous on 10/19/2019
Species: Human
Mixture of 100 microM of glycine + 100 microM NMDA was used to evoke an NMDA receptor response in outside-out patched excised from hippocampal neurons. Glycine displayed a clear co-agonist effect, as expected. Easily soluble, no problem if stored in frozen aliquots for more than half a year.
For experiments with NMDA receptors use of D-Serine is sometimes better.
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