One of the major inhibitory neurotransmitters in the mammalian CNS, predominantly active in the spinal cord and brain stem. Also acts as a modulator of excitatory amino acid transmission mediated by NMDA receptors. Also available as part of the NMDA Receptor - Glycine Site Tocriset™.
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 100 mM in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 75.07. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||13.32 mL||66.6 mL||133.21 mL|
|5 mM||2.66 mL||13.32 mL||26.64 mL|
|10 mM||1.33 mL||6.66 mL||13.32 mL|
|50 mM||0.27 mL||1.33 mL||2.66 mL|
The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.
References are publications that support the products' biological activity.
Betz (1991) Glycine receptors: heterogeneous and widespread in the mammalian brain. Trends Neurosci. 14 458 PMID: 1722365
Kuhse et al (1995) The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex. Curr.Opin.Neurobiol. 5 318 PMID: 7850154
If you know of a relevant reference for Glycine, please let us know.
Keywords: Endogenous glycine receptor agonists potentiator co-transmitter GlyR Glycine Receptors Glutamate NMDA N-Methyl-D-Aspartate iGluR Ionotropic NMDA Receptors
2 Citations for Glycine
Citations are publications that use Tocris products. Selected citations for Glycine include:
Kaushal and Schlichter (2008) Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. J Neurosci 28 2221 PMID: 18305255
Sivakumaran et al (2015) Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo. Front Cell Neurosci 35 8291 PMID: 26019342
Do you know of a great paper that uses Glycine from Tocris? If so please let us know.
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