Glycine

Pricing Availability   Qty
Description: Endogenous potentiator of NMDA receptors
Chemical Name: Aminoethanoic acid
Datasheet
Citations (4)
Reviews (1)
Literature (5)

Biological Activity for Glycine

One of the major inhibitory neurotransmitters in the mammalian CNS, predominantly active in the spinal cord and brain stem. Also acts as a modulator of excitatory amino acid transmission mediated by NMDA receptors.

Technical Data for Glycine

M. Wt 75.07
Formula C2H5NO2
Storage Store at RT
CAS Number 56-40-6
PubChem ID 750
InChI Key DHMQDGOQFOQNFH-UHFFFAOYSA-N
Smiles NCC(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Glycine

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 100

Preparing Stock Solutions for Glycine

The following data is based on the product molecular weight 75.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 13.32 mL 66.6 mL 133.21 mL
5 mM 2.66 mL 13.32 mL 26.64 mL
10 mM 1.33 mL 6.66 mL 13.32 mL
50 mM 0.27 mL 1.33 mL 2.66 mL

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Product Datasheets for Glycine

Certificate of Analysis / Product Datasheet
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References for Glycine

References are publications that support the biological activity of the product.

Betz (1991) Glycine receptors: heterogeneous and widespread in the mammalian brain. Trends Neurosci. 14 458 PMID: 1722365

Kuhse et al (1995) The inhibitory glycine receptor: architecture, synaptic localization and molecular pathology of a postsynaptic ion-channel complex. Curr.Opin.Neurobiol. 5 318 PMID: 7850154

Ascher and Johnson (1989) The NMDA receptor, its channel and its modulation by glycine. The NMDA Receptor (2nd edition). Eds. G.L.Collingr 109

Johnson and Ascher (1987) Glycine potentiates the NMDA response in cultured mouse brain neurons. Nature 325 529


If you know of a relevant reference for Glycine, please let us know.

View Related Products by Product Action

View all NMDA Receptor Modulators

Keywords: Glycine, Glycine supplier, Endogenous, glycine, receptor, agonists, potentiator, co-transmitter, GlyR, Glycine, Receptors, Glutamate, NMDA, N-Methyl-D-Aspartate, iGluR, Ionotropic, 0219, Tocris Bioscience

4 Citations for Glycine

Citations are publications that use Tocris products. Selected citations for Glycine include:

Kenny et al (2009) The integrity of the glycine co-agonist binding site of N-MthD.-aspartate receptors is a functional quality control checkpoint for cell surface delivery. J Biol Chem 284 324 PMID: 18990687

Sivakumaran et al (2015) Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo. Front Cell Neurosci 35 8291 PMID: 26019342

Hangen et al (2018) Neuronal Activity and Intracellular Calcium Levels Regulate Intracellular Transport of Newly Synthesized AMPAR. Cell Rep 24 1001 PMID: 30044968

Kaushal and Schlichter (2008) Mechanisms of microglia-mediated neurotoxicity in a new model of the stroke penumbra. J Neurosci 28 2221 PMID: 18305255


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Reviews for Glycine

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Use of glycine as NMDA receptor co-agonist.
By Anonymous on 10/19/2019
Species: Human

Mixture of 100 microM of glycine + 100 microM NMDA was used to evoke an NMDA receptor response in outside-out patched excised from hippocampal neurons. Glycine displayed a clear co-agonist effect, as expected. Easily soluble, no problem if stored in frozen aliquots for more than half a year.

For experiments with NMDA receptors use of D-Serine is sometimes better.

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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