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Farnesoid X receptor (FXR) antagonist. Accumulates in ileum and inhibits FXR signaling exclusively in intestine. Inhibits or reverses high-fat diet-induced and genetic obesity, insulin resistance and hepatic steatosis in mice. Reduces obesity and metabolic syndrome in obese mice. Orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 465.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.15 mL||10.74 mL||21.48 mL|
|5 mM||0.43 mL||2.15 mL||4.3 mL|
|10 mM||0.21 mL||1.07 mL||2.15 mL|
|50 mM||0.04 mL||0.21 mL||0.43 mL|
References are publications that support the biological activity of the product.
Jiang et al (2015) Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nat.Commun. 6 10166 PMID: 26670557
Wahlström et al (2016) Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab. 24 41 PMID: 27320064
Clemmensen et al (2017) Gut-brain cross-talk in metabolic control. Cell 168 758 PMID: 28235194
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Keywords: Gly MCA, Gly MCA supplier, GlyMCA, farnesoid, X, receptor, FXR, antagonists, antagonsim, obesity, insulin, resistance, diabetes, orally, bioavailable, LXR-like, Receptors, 6669, Tocris Bioscience
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