Discontinued Product

Gly MCA (Cat. No. 6669) has been withdrawn from sale for commercial reasons.
Description: FXR antagonist; selectively active in intestines; orally bioavailable
Chemical Name: N-[(3α,5β,6β,7β)-3,6,7-Trihydroxy-24-oxocholan-24-yl]glycine

Biological Activity for Gly MCA

Gly MCA is a farnesoid X receptor (FXR) antagonist. Accumulates in ileum and inhibits FXR signaling exclusively in intestine. Inhibits or reverses high-fat diet-induced and genetic obesity, insulin resistance and hepatic steatosis in mice. Reduces obesity and metabolic syndrome in obese mice. Orally bioavailable.

Technical Data for Gly MCA

M. Wt 465.62
Formula C26H43NO6
Storage Store at -20°C
CAS Number 66225-78-3
PubChem ID 131675923
Smiles [H][C@]1([C@@H](CCC(NCC(O)=O)=O)C)CC[C@]2([C@@]3([C@H]([C@H]([C@@]4(C[C@@H](CC[C@@]4([C@]3(CC[C@]12C)[H])C)O)[H])O)O)[H])[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Gly MCA

References are publications that support the biological activity of the product.

Jiang et al (2015) Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nat.Commun. 6 10166 PMID: 26670557

Wahlström et al (2016) Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab. 24 41 PMID: 27320064

Clemmensen et al (2017) Gut-brain cross-talk in metabolic control. Cell 168 758 PMID: 28235194

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Keywords: Gly MCA, Gly MCA supplier, GlyMCA, farnesoid, X, receptor, FXR, antagonists, antagonsim, obesity, insulin, resistance, diabetes, orally, bioavailable, LXR-like, Receptors, 6669, Tocris Bioscience

Citations for Gly MCA

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Currently there are no citations for Gly MCA.

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