Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Gly MCA is a farnesoid X receptor (FXR) antagonist. Accumulates in ileum and inhibits FXR signaling exclusively in intestine. Inhibits or reverses high-fat diet-induced and genetic obesity, insulin resistance and hepatic steatosis in mice. Reduces obesity and metabolic syndrome in obese mice. Orally bioavailable.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
The following data is based on the product molecular weight 465.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.15 mL||10.74 mL||21.48 mL|
|5 mM||0.43 mL||2.15 mL||4.3 mL|
|10 mM||0.21 mL||1.07 mL||2.15 mL|
|50 mM||0.04 mL||0.21 mL||0.43 mL|
References are publications that support the biological activity of the product.
Jiang et al (2015) Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nat.Commun. 6 10166 PMID: 26670557
Wahlström et al (2016) Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab. 24 41 PMID: 27320064
Clemmensen et al (2017) Gut-brain cross-talk in metabolic control. Cell 168 758 PMID: 28235194
If you know of a relevant reference for Gly MCA, please let us know.
Keywords: Gly MCA, Gly MCA supplier, GlyMCA, farnesoid, X, receptor, FXR, antagonists, antagonsim, obesity, insulin, resistance, diabetes, orally, bioavailable, LXR-like, Receptors, 6669, Tocris Bioscience
Citations are publications that use Tocris products.
Currently there are no citations for Gly MCA. Do you know of a great paper that uses Gly MCA from Tocris? Please let us know.
There are currently no reviews for this product. Be the first to review Gly MCA and earn rewards!
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.