Gly MCA

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Cat.No. 6669 - Gly MCA | C26H43NO6 | CAS No. 66225-78-3
Description: FXR antagonist; selectively active in intestines; orally bioavailable
Chemical Name: N-[(3α,5β,6β,7β)-3,6,7-Trihydroxy-24-oxocholan-24-yl]glycine
Datasheet
Citations
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Literature

Biological Activity

Farnesoid X receptor (FXR) antagonist. Accumulates in ileum and inhibits FXR signaling exclusively in intestine. Inhibits or reverses high-fat diet-induced and genetic obesity, insulin resistance and hepatic steatosis in mice. Reduces obesity and metabolic syndrome in obese mice. Orally bioavailable.

Technical Data

M. Wt 465.62
Formula C26H43NO6
Storage Store at -20°C
CAS Number 66225-78-3
PubChem ID 131675923
InChI Key ZQYUKJFJPJDMMR-DLUUSONCSA-N
Smiles [H][C@]1([C@@H](CCC(NCC(O)=O)=O)C)CC[C@]2([C@@]3([C@H]([C@H]([C@@]4(C[C@@H](CC[C@@]4([C@]3(CC[C@]12C)[H])C)O)[H])O)O)[H])[H]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 46.56 100
ethanol 23.28 50

Preparing Stock Solutions

The following data is based on the product molecular weight 465.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.15 mL 10.74 mL 21.48 mL
5 mM 0.43 mL 2.15 mL 4.3 mL
10 mM 0.21 mL 1.07 mL 2.15 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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References

References are publications that support the biological activity of the product.

Jiang et al (2015) Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nat.Commun. 6 10166 PMID: 26670557

Wahlström et al (2016) Intestinal crosstalk between bile acids and microbiota and its impact on host metabolism. Cell Metab. 24 41 PMID: 27320064

Clemmensen et al (2017) Gut-brain cross-talk in metabolic control. Cell 168 758 PMID: 28235194


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