Discontinued ProductUnfortunately GGTI 297 (Cat. No. 2774) has been withdrawn from sale for commercial reasons.
Geranylgeranyltransferase I (GGTase-I) inhibitor (IC50 values are 135 and 418 nM for GGTase-I and FTase inhibition respectively). Inhibits RhoA prenylation leading to inactivation of RhoA/ROCK and a decrease in basal tone of the internal anal sphincter in vitro.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Preparing Stock Solutions
The following data is based on the product molecular weight 579.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.73 mL||8.63 mL||17.25 mL|
|5 mM||0.35 mL||1.73 mL||3.45 mL|
|10 mM||0.17 mL||0.86 mL||1.73 mL|
|50 mM||0.03 mL||0.17 mL||0.35 mL|
References are publications that support the products' biological activity.
Patel et al (2007) RhoA prenylation inhibitor produces relaxation of tonic smooth muscle of internal anal sphincter. J.Pharmacol.Exp.Ther. 32 501 PMID: 17322025
Qian (1998) Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics. Bioorg.Med.Chem. 6 293 PMID: 9568283
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Keywords: GGTI 297, supplier, GGTI297, geranylgeranyltransferase-I, GGTase-I, geranyl, inhibitors, inhibits, FTase, RhoA, prenylation, ROCK, Protein, Prenyltransferases, Protein, Prenyltransferases, Tocris Bioscience
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