GGTI 297

Discontinued Product

GGTI 297 (Cat. No. 2774) has been withdrawn from sale for commercial reasons.
Cat.No. 2774 - GGTI 297 | C26H31N3O3S.CF3CO2H
Description: Geranylgeranyltransferase I (GGTase I) inhibitor
Chemical Name: N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucine trifluoroacetate salt
Purity: ≥95% (HPLC)
Datasheet
Citations
Reviews
Literature

Biological Activity

Geranylgeranyltransferase I (GGTase-I) inhibitor (IC50 values are 135 and 418 nM for GGTase-I and FTase inhibition respectively). Inhibits RhoA prenylation leading to inactivation of RhoA/ROCK and a decrease in basal tone of the internal anal sphincter in vitro.

Technical Data

M. Wt 579.63
Formula C26H31N3O3S.CF3CO2H
Storage Store at -20°C
Purity ≥95% (HPLC)
PubChem ID 90488779
Smiles SC[C@H](N)CNC1=CC=C(C(N[C@H]([C@@](O)=O)CC(C)C)=O)C(C2=CC=CC3=C2C=CC=C3)=C1.FC(F)(F)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References

References are publications that support the biological activity of the product.

Patel et al (2007) RhoA prenylation inhibitor produces relaxation of tonic smooth muscle of internal anal sphincter. J.Pharmacol.Exp.Ther. 32 501 PMID: 17322025

Qian (1998) Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics. Bioorg.Med.Chem. 6 293 PMID: 9568283

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Keywords: GGTI 297, GGTI 297 supplier, GGTI297, geranylgeranyltransferase-I, GGTase-I, geranyl, inhibitors, inhibits, FTase, RhoA, prenylation, ROCK, Protein, Prenyltransferases, 2774, Tocris Bioscience

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