GGTI 297

Discontinued Product

Unfortunately GGTI 297 (Cat. No. 2774) has been withdrawn from sale for commercial reasons.
Cat.No. 2774 - GGTI 297 | C26H31N3O3S.CF3CO2H
Description: Geranylgeranyltransferase I (GGTase I) inhibitor
Chemical Name: N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-(1-naphthalenyl)benzoyl]-L-leucine trifluoroacetate salt
Purity: ≥95% (HPLC)

Biological Activity

Geranylgeranyltransferase I (GGTase-I) inhibitor (IC50 values are 135 and 418 nM for GGTase-I and FTase inhibition respectively). Inhibits RhoA prenylation leading to inactivation of RhoA/ROCK and a decrease in basal tone of the internal anal sphincter in vitro.

Technical Data

M. Wt 579.63
Formula C26H31N3O3S.CF3CO2H
Storage Store at -20°C
Purity ≥95% (HPLC)
PubChem ID 90488779
Smiles SC[C@H](N)CNC1=CC=C(C(N[C@H]([C@@](O)=O)CC(C)C)=O)C(C2=CC=CC3=C2C=CC=C3)=C1.FC(F)(F)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Preparing Stock Solutions

The following data is based on the product molecular weight 579.63. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.73 mL 8.63 mL 17.25 mL
5 mM 0.35 mL 1.73 mL 3.45 mL
10 mM 0.17 mL 0.86 mL 1.73 mL
50 mM 0.03 mL 0.17 mL 0.35 mL

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Product Datasheets

Safety Datasheet


References are publications that support the products' biological activity.

Patel et al (2007) RhoA prenylation inhibitor produces relaxation of tonic smooth muscle of internal anal sphincter. J.Pharmacol.Exp.Ther. 32 501 PMID: 17322025

Qian (1998) Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics. Bioorg.Med.Chem. 6 293 PMID: 9568283

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Keywords: GGTI 297, supplier, GGTI297, geranylgeranyltransferase-I, GGTase-I, geranyl, inhibitors, inhibits, FTase, RhoA, prenylation, ROCK, Protein, Prenyltransferases, Protein, Prenyltransferases, Tocris Bioscience

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