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Selective, irreversible γ-glutamyl transpeptidase (GGT) inhibitor; displays no inhibitory effects on glutamine amidotransferases or asparagine synthetase. Suppresses oxidative stress by inhibiting GGT activation. Prevents ischemia/reperfusion-induced acute kidney injury in rats in vivo.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 331.26. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||6.04 mL||30.19 mL||60.38 mL|
|2.5 mM||1.21 mL||6.04 mL||12.08 mL|
|5 mM||0.6 mL||3.02 mL||6.04 mL|
|25 mM||0.12 mL||0.6 mL||1.21 mL|
References are publications that support the biological activity of the product.
Han et al (2007) Design, synthesis, and evaluation of γ-phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of γ-glutamyl transpeptidase. Biochemistry 46 1432 PMID: 17260973
Yamamoto et al (2011) Preventive effect of GGsTop, a novel and selective γ-glutamyl transpeptidase inhibitor, on ischemia/reperfusion-induced renal injury in rats. J.Pharmacol.Exp.Ther. 339 945 PMID: 21937737
If you know of a relevant reference for GGsTop, please let us know.
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Keywords: GGsTop, GGsTop supplier, GGsTop, GGT, inhibitors, inhibits, g-GGT, gamma-GGT, γ-GGT, glutamyltransferases, Glutamyl, Transpeptidase, Ischemia, ischaemia, oxidative, stress, Other, Transferases, 4452, Tocris Bioscience
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