GGsTop

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Cat.No. 4452 - GGsTop | C13H18NO7P | CAS No. 926281-37-0
Description: Inhibitor of γ-glutamyl transpeptidase (GGT)
Chemical Name: 3-[[(3-Amino-3-carboxypropyl)methoxyphosphinyl]oxy]benzeneacetic acid
Purity: ≥95% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Selective, irreversible γ-glutamyl transpeptidase (GGT) inhibitor; displays no inhibitory effects on glutamine amidotransferases or asparagine synthetase. Suppresses oxidative stress by inhibiting GGT activation. Prevents ischemia/reperfusion-induced acute kidney injury in rats in vivo.

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Technical Data

M. Wt 331.26
Formula C13H18NO7P
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 926281-37-0
PubChem ID 23582776
InChI Key NTFPDEDRMYYPAC-UHFFFAOYSA-N
Smiles NC(C(O)=O)CCP(OC1=CC=CC(CC(O)=O)=C1)(OC)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 33.13 100
water 33.13 100

Preparing Stock Solutions

The following data is based on the product molecular weight 331.26. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.02 mL 15.09 mL 30.19 mL
5 mM 0.6 mL 3.02 mL 6.04 mL
10 mM 0.3 mL 1.51 mL 3.02 mL
50 mM 0.06 mL 0.3 mL 0.6 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the products' biological activity.

Han et al (2007) Design, synthesis, and evaluation of γ-phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of γ-glutamyl transpeptidase. Biochemistry 46 1432 PMID: 17260973

Yamamoto et al (2011) Preventive effect of GGsTop, a novel and selective γ-glutamyl transpeptidase inhibitor, on ischemia/reperfusion-induced renal injury in rats. J.Pharmacol.Exp.Ther. 339 945 PMID: 21937737


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Keywords: GGsTop GGT inhibitors inhibits g-GGT gamma-GGT γ-GGT glutamyltransferases Glutamyl Transpeptidase Ischemia ischaemia oxidative stress Other Transferases

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