Gap 27

Pricing Availability   Qty
Description: Selective gap junction blocker
Purity: ≥95% (HPLC)
Datasheet
Citations (2)
Reviews

Biological Activity for Gap 27

Gap 27 is a peptide derived from connexin 43 that is a selective gap junction blocker. Attenuates ACh-induced arterial relaxation and reduces K+-mediated smooth muscle repolarization in endothelium-intact vessels in vitro.

Technical Data for Gap 27

M. Wt 1304.55
Formula C60H101N15O17
Sequence SRPTEKTIFII
Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 198284-64-9
PubChem ID 9920128
InChI Key SXRAPDIXXYFGJG-MDAHIHQXSA-N
Smiles [H]N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Gap 27

Solubility Soluble to 1 mg/ml in water

Product Datasheets for Gap 27

Certificate of Analysis / Product Datasheet
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References for Gap 27

References are publications that support the biological activity of the product.

Chaytor et al (1998) Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J.Physiol. 508 561 PMID: 9508817

Ko et al (2000) Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts. Am.J.Physiol.Cell Physiol. 279 C147 PMID: 10898726

Richards et al (2001) Suppression of K+-induced hyperpolarization by phenylephrine in rat mesenteric artery: relevance to studies of endothelium-derived hyperpolarizing factor. Br.J.Pharmacol. 134 1 PMID: 11522590


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Keywords: Gap 27, Gap 27 supplier, Selective, gap, junction, blockers, Connexins, Gap, Channels, modulators, Gap27, 1476, Tocris Bioscience

2 Citations for Gap 27

Citations are publications that use Tocris products. Selected citations for Gap 27 include:

Dosch et al (2019) Connexin-43-dependent ATP release mediates macrophage activation during sepsis. Elife 8 PMID: 30735126

Westphalen et al (2014) Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity. Nature 506 503 PMID: 24463523


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