Peptide derived from connexin 43 that is a selective gap junction blocker. Attenuates ACh-induced arterial relaxation and reduces K+-mediated smooth muscle repolarization in endothelium-intact vessels in vitro.
|Storage||Desiccate at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
|Solubility||Soluble to 1 mg/ml in water|
Preparing Stock Solutions
The following data is based on the product molecular weight 1304.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||0.77 mL||3.83 mL||7.67 mL|
|5 mM||0.15 mL||0.77 mL||1.53 mL|
|10 mM||0.08 mL||0.38 mL||0.77 mL|
|50 mM||0.02 mL||0.08 mL||0.15 mL|
References are publications that support the biological activity of the product.
Chaytor et al (1998) Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J.Physiol. 508 561 PMID: 9508817
Ko et al (2000) Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts. Am.J.Physiol.Cell Physiol. 279 C147 PMID: 10898726
Richards et al (2001) Suppression of K+-induced hyperpolarization by phenylephrine in rat mesenteric artery: relevance to studies of endothelium-derived hyperpolarizing factor. Br.J.Pharmacol. 134 1 PMID: 11522590
If you know of a relevant reference for Gap 27, please let us know.
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Keywords: Gap 27, Gap 27 supplier, Selective, gap, junction, blockers, Connexins, Gap, Channels, modulators, Gap27, 1476, Tocris Bioscience
1 Citation for Gap 27
Citations are publications that use Tocris products. Selected citations for Gap 27 include:
Westphalen et al (2014) Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity. Nature 506 503 PMID: 24463523
Do you know of a great paper that uses Gap 27 from Tocris? Please let us know.
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Literature in this Area
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