Gap 27

Pricing Availability Delivery Time Qty
Cat.No. 1476 - Gap 27 | Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile | CAS No. 198284-64-9
Description: Selective gap junction blocker
Datasheet
Citations (1)
Literature

Biological Activity

Peptide derived from connexin 43 that is a selective gap junction blocker. Attenuates ACh-induced arterial relaxation and reduces K+-mediated smooth muscle repolarization in endothelium-intact vessels in vitro.

Technical Data

M. Wt 1304.55
Formula C60H101N15O17
Sequence SRPTEKTIFII
Storage Desiccate at -20°C
CAS Number 198284-64-9
PubChem ID 9920128
InChI Key SXRAPDIXXYFGJG-MDAHIHQXSA-N
Smiles [H]N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 1 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1304.55. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.77 mL 3.83 mL 7.67 mL
5 mM 0.15 mL 0.77 mL 1.53 mL
10 mM 0.08 mL 0.38 mL 0.77 mL
50 mM 0.02 mL 0.08 mL 0.15 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Chaytor et al (1998) Central role of heterocellular gap junctional communication in endothelium-dependent relaxations of rabbit arteries. J.Physiol. 508 561 PMID: 9508817

Ko et al (2000) Biochemical and functional characterization of intercellular adhesion and gap junctions in fibroblasts. Am.J.Physiol.Cell Physiol. 279 C147 PMID: 10898726

Richards et al (2001) Suppression of K+-induced hyperpolarization by phenylephrine in rat mesenteric artery: relevance to studies of endothelium-derived hyperpolarizing factor. Br.J.Pharmacol. 134 1 PMID: 11522590


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Keywords: Selective gap junction blockers Connexins Gap Channels modulators Gap27 Gap Channels

1 Citation for Gap 27

Citations are publications that use Tocris products. Selected citations for Gap 27 include:

Westphalen et al (2014) Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity. Nature 506 503 PMID: 24463523


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Literature in this Area

Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
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