Gap 26

Pricing Availability Delivery Time Qty
Cat.No. 1950 - Gap 26 | Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg | CAS No. 197250-15-0
Description: Gap junction blocker; inhibits smooth muscle contraction and IP3-mediated ATP release
Datasheet
Citations (3)
Literature

Biological Activity

Peptide, corresponding to residues 63 - 75 of connexin 43, which is a gap junction blocker. Attenuates rhythmic contractile activity of rabbit arterial smooth muscle (IC50 = 28.4 μM). Also inhibits IP3-induced ATP release, without inhibiting gap junctional coupling in endothelial cells.

Technical Data

M. Wt 1550.79
Formula C70H107N19O19S
Sequence VCYDKSFPISHVR
Storage Desiccate at -20°C
CAS Number 197250-15-0
PubChem ID 25088334
InChI Key FDPIMWZHGJNESB-VCSXYVMHSA-N
Smiles [H]N[C@@H](C(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

SolubilitySoluble to 2 mg/ml in water

Preparing Stock Solutions

The following data is based on the product molecular weight 1550.79. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 0.64 mL 3.22 mL 6.45 mL
5 mM 0.13 mL 0.64 mL 1.29 mL
10 mM 0.06 mL 0.32 mL 0.64 mL
50 mM 0.01 mL 0.06 mL 0.13 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Braet et al (2003) Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium 33 37 PMID: 12526886

Chaytor et al (1997) Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J.Physiol. 503 99 PMID: 9288678


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Keywords: Gap junction blockers connexin 43 channels modulators Gap26 Gap Channels

3 Citations for Gap 26

Citations are publications that use Tocris products. Selected citations for Gap 26 include:

Jones et al (2015) Evidence for bystander signalling between human trophoblast cells and human embryonic stem cells. Sci Rep 5 11694 PMID: 26170169

Thuringer et al (2015) Oncogenic extracellular HSP70 disrupts the gap-junctional coupling between capillary cells. BMC Vet Res 6 10267 PMID: 25868858

Sakatani et al (2008) Neural-activity-dependent release of S100B from astrocytes enhances kainate-induced gamma oscillations in vivo. J Neurosci 28 10928 PMID: 18945900


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Cancer

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

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