G10

Cat. No. 5944 Submit a Review Datasheet / COA / SDS

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Description: Activator of STING-dependent signaling

Chemical Name: 4-[(2-Chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide

Purity: ≥98% (HPLC)

Datasheet

Citations

Reviews

Literature (1)

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for G10

G10 is an activator of STING-dependent signaling; exhibits no direct binding affinity for STING. Stimulates IRF-3-induced transcription and induces IFNα and IFNγ gene expression in human fibroblasts. Exhibits no effect on NF-κB signaling. Blocks viral replication in vitro.

Compound Libraries for G10

G10 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for G10

M. Wt	430.88
Formula	C₂₁H₁₆ClFN₂O₃S
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	702662-50-8
PubChem ID	5077622
InChI Key	NAGKYJATVFXZKN-UHFFFAOYSA-N
Smiles	FC1=CC=CC(Cl)=C1CN2C(CSC3=CC=C(C(NCC4=CC=CO4)=O)C=C23)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for G10

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	43.09	100

Preparing Stock Solutions for G10

The following data is based on the product molecular weight 430.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.32 mL	11.6 mL	23.21 mL
5 mM	0.46 mL	2.32 mL	4.64 mL
10 mM	0.23 mL	1.16 mL	2.32 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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Product Datasheets for G10

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for G10

References are publications that support the biological activity of the product.

Sali et al (2015) Characterization of a novel human-specific STING agonist that elicits antiviral activity against emerging alphaviruses. PLoS Pathog. 11 e1005324 PMID: 26646986

If you know of a relevant reference for G10, please let us know.

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Keywords: G10, G10 supplier, STING-dependent, signaling, activators, activates, interferons, IRF3, antiviral, STING-Dependent, Signaling, 5944, Tocris Bioscience

Citations for G10

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Literature in this Area

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Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

Chemokine and Cytokine Signaling
Chemotaxis
Complement System
Immune Cell Signaling
Inflammation

G10