You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!Submit Review
Biological Activity for FSLLRY-NH2
FSLLRY-NH2 is a selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch. FSLLRY-NH2 inhibits C. albicans induced inflammation in oral mucosal cells in vitro.
Technical Data for FSLLRY-NH2
(Modifications: Tyr-6 = C-terminal amide)
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for FSLLRY-NH2
|Solubility||Soluble to 1 mg/ml in water|
References for FSLLRY-NH2
References are publications that support the biological activity of the product.
McLarty et al (2011) Tryptase/protease-activated receptor 2 interactions induce selective mitogen-activated protein kinase signaling and collagen synthesis by cardiac fibroblasts. Hypertension 58 264 PMID: 21730297
Chen et al (2011) Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in PacT.-induced neuropathic pain. Neuroscience 193 440 PMID: 21763756
Andoh et al (2012) Involvement of serine protease and proteinase-activated receptor 2 in dermatophyte-associated itch in mice. J.Pharmacol.Exp.Ther. 343 91 PMID: 22761302
Kumar et al (2022) Candida albicans Sap6 initiates oral mucosal inflammation via the protease activated receptor PAR2. Front.Immunol. 13 912748 PMID: 35844627
If you know of a relevant reference for FSLLRY-NH2, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: FSLLRY-NH2, FSLLRY-NH2 supplier, PAR2, protease, activated, receptors, selective, antagonists, Protease-Activated, Receptors, 4751, Tocris Bioscience
9 Citations for FSLLRY-NH2
Citations are publications that use Tocris products. Selected citations for FSLLRY-NH2 include:
Bao et al (2014) PAR2-mediated upregulation of BDNF contributes to central sensitization in bone cancer pain. Mol Pain 10 28 PMID: 24886294
Tripathi et al (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci 55 3912 PMID: 24876278
Noskovičová et al (2018) Cub domain-containing protein 1 negatively regulates TGF-β signaling and myofibroblast differentiation. Am J Physiol Lung Cell Mol Physiol 314 L695 PMID: 29351434
Eum et al (2014) Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases. Am J Physiol Gastrointest Liver Physiol 306 G992 PMID: 24742991
Kumar et al (2022) Candida albicans Sap6 initiates oral mucosal inflammation via the protease activated receptor PAR2. Front Immunl 13 912748 PMID: 35844627
Nithin D et al (2020) Polarization of protease-activated receptor 2 (PAR-2) signaling is altered during airway epithelial remodeling and deciliation. J Biol Chem 295 6721-6740 PMID: 32241907
White et al (2015) A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid P. Cell Death Dis 194 142 PMID: 25429068
Xianglan et al (2019) Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1β secretion by bronchoalveolar fluid macrophages from asthmatic subjects. J Allergy Clin Immunol 144 426-441.e3 PMID: 30872118
Peng et al (2016) Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2 Phil. Trans. R. Soc. B 371 1700 PMID: 27377732
Do you know of a great paper that uses FSLLRY-NH2 from Tocris? Please let us know.
Reviews for FSLLRY-NH2
There are currently no reviews for this product. Be the first to review FSLLRY-NH2 and earn rewards!
Have you used FSLLRY-NH2?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image