FSLLRY-NH2

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Description: PAR2 peptide antagonist
Purity: ≥95% (HPLC)
Datasheet
Citations (9)
Reviews

Biological Activity for FSLLRY-NH2

FSLLRY-NH2 is a selective PAR2 peptide antagonist. Reverses taxol-induced mechanical allodynia, heat hyperalgesia and PKC activation in ICR mice. Blocks ERK activation and collagen production in isolated cardiac fibroblasts. Also reduces symptoms in a mouse model of dermatophyte-associated itch. FSLLRY-NH2 inhibits C. albicans induced inflammation in oral mucosal cells in vitro.

Technical Data for FSLLRY-NH2

M. Wt 796.97
Formula C39H60N10O8
Sequence FSLLRY

(Modifications: Tyr-6 = C-terminal amide)

Storage Store at -20°C
Purity ≥95% (HPLC)
CAS Number 245329-02-6
PubChem ID 73352412
InChI Key KMSCNWHRNILNRJ-JNRWAQIZSA-N
Smiles [H]N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(N)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FSLLRY-NH2

Solubility Soluble to 1 mg/ml in water

Product Datasheets for FSLLRY-NH2

Certificate of Analysis / Product Datasheet
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Keywords: FSLLRY-NH2, FSLLRY-NH2 supplier, PAR2, protease, activated, receptors, selective, antagonists, Protease-Activated, Receptors, 4751, Tocris Bioscience

9 Citations for FSLLRY-NH2

Citations are publications that use Tocris products. Selected citations for FSLLRY-NH2 include:

White et al (2015) A brief exposure to tryptase or thrombin potentiates fibrocyte differentiation in the presence of serum or serum amyloid P. Cell Death Dis 194 142 PMID: 25429068

Bao et al (2014) PAR2-mediated upregulation of BDNF contributes to central sensitization in bone cancer pain. Mol Pain 10 28 PMID: 24886294

Tripathi et al (2014) Protease-activated receptor 2 (PAR2) is upregulated by Acanthamoeba plasminogen activator (aPA) and induces proinflammatory cytokine in human corneal epithelial cells. Invest Ophthalmol Vis Sci 55 3912 PMID: 24876278

Kumar et al (2022) Candida albicans Sap6 initiates oral mucosal inflammation via the protease activated receptor PAR2. Front Immunl 13 912748 PMID: 35844627


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