FR 171113

Pricing Availability   Qty

Save up to 40% on RUO Reagents with BIOSPRING24 (see details)

Description: PAR1 antagonist
Chemical Name: 2-[3-(4-Chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid methyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews (1)

Biological Activity for FR 171113

FR 171113 is a protease-activated receptor 1 (PAR1) antagonist. Exhibits potent antiplatelet activity in vitro; inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM) with no effect on coagulation time.

Technical Data for FR 171113

M. Wt 469.73
Formula C19H11Cl3N2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 173904-50-2
PubChem ID 25015749
InChI Key SDGLYCKTPKZBGI-DALCUZTNSA-N
Smiles O=C(/N=C(N(C3=CC=C(Cl)C=C3)C2=O)\S/C2=C/C(OC)=O)C1=CC=C(Cl)C=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FR 171113

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.7 10

Preparing Stock Solutions for FR 171113

The following data is based on the product molecular weight 469.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.29 mL 106.44 mL 212.89 mL
0.5 mM 4.26 mL 21.29 mL 42.58 mL
1 mM 2.13 mL 10.64 mL 21.29 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

References for FR 171113

References are publications that support the biological activity of the product.

Kato et al (1999) In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist. Eur.J.Pharmacol. 384 197 PMID: 10611442

Kato et al (2003) Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig. Eur.J.Pharmacol. 473 163 PMID: 12892834


If you know of a relevant reference for FR 171113, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Protease-Activated Receptor Antagonists

Keywords: FR 171113, FR 171113 supplier, FR171113, thrombin, protease-activated, receptor, 1, PAR1, antagonist, antagonists, antithrombotic, antiplatelet, Protease-Activated, Receptors, 3643, Tocris Bioscience

1 Citation for FR 171113

Citations are publications that use Tocris products. Selected citations for FR 171113 include:

Eum et al (2014) Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases. Am J Physiol Gastrointest Liver Physiol 306 G992 PMID: 24742991


Do you know of a great paper that uses FR 171113 from Tocris? Please let us know.

Reviews for FR 171113

Average Rating: 3 (Based on 1 Review.)

5 Star
0%
4 Star
0%
3 Star
100%
2 Star
0%
1 Star
0%

Have you used FR 171113?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Filter by:


PAR1 antagonism not awesome - perhaps SCH compound a better choice.
By Andrew Randall on 10/17/2019
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: Brain Pericytes

To attempt to block TRAP6 mediated Ca2+ mobilization in human pericytes. Its lack of potency and low solubility means it was not especially effective even with sub-maximal agonist concentrations - some antagonism or slowing of response - but not the complete block I had hoped for even when pre-equilibrated prior to agonist activation. We will now save our pennies to try the more potent SCH PAR1 antag

Really could not get this to dissolve at 10 mM in DMSO as website suggests - probably goes in around 7 mM. As this is not a very potent antagonist you will need to have quite a bit of DMSO around to get even partial antagonism.