FR 171113

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Cat.No. 3643 - FR 171113 | C19H11Cl3N2O4S | CAS No. 173904-50-2
Description: PAR1 antagonist
Chemical Name: 2-[3-(4-Chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid methyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (3)

Biological Activity

Protease-activated receptor 1 (PAR1) antagonist. Exhibits potent antiplatelet activity in vitro; inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM) with no effect on coagulation time.

Technical Data

M. Wt 469.73
Formula C19H11Cl3N2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 173904-50-2
PubChem ID 25015749
InChI Key SDGLYCKTPKZBGI-DALCUZTNSA-N
Smiles O=C(/N=C(N(C3=CC=C(Cl)C=C3)C2=O)\S/C2=C/C(OC)=O)C1=CC=C(Cl)C=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.7 10

Preparing Stock Solutions

The following data is based on the product molecular weight 469.73. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 21.29 mL 106.44 mL 212.89 mL
0.5 mM 4.26 mL 21.29 mL 42.58 mL
1 mM 2.13 mL 10.64 mL 21.29 mL
5 mM 0.43 mL 2.13 mL 4.26 mL

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References

References are publications that support the biological activity of the product.

Kato et al (1999) In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist. Eur.J.Pharmacol. 384 197 PMID: 10611442

Kato et al (2003) Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig. Eur.J.Pharmacol. 473 163 PMID: 12892834


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Keywords: FR 171113, FR 171113 supplier, FR171113, thrombin, protease-activated, receptor, 1, PAR1, antagonist, antagonists, antithrombotic, antiplatelet, Protease-Activated, Receptors, 3643, Tocris Bioscience

1 Citation for FR 171113

Citations are publications that use Tocris products. Selected citations for FR 171113 include:

Eum et al (2014) Disruption of epithelial barrier by quorum-sensing N-3-(oxododecanoyl)-homoserine lactone is mediated by matrix metalloproteinases. Am J Physiol Gastrointest Liver Physiol 306 G992 PMID: 24742991


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Literature in this Area

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