FR 171113

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Cat.No. 3643 - FR 171113 | C19H11Cl3N2O4S | CAS No. 173904-50-2
Description: PAR1 antagonist
Chemical Name: 2-[3-(4-Chlorophenyl)-2-[(2,4-dichlorobenzoyl)imino]-4-oxo-5-thiazolidinylidene]-acetic acid methyl ester
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Protease-activated receptor 1 (PAR1) antagonist. Exhibits potent antiplatelet activity in vitro; inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM) with no effect on coagulation time.

Technical Data

M. Wt 469.73
Formula C19H11Cl3N2O4S
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 173904-50-2
PubChem ID 25015749
InChI Key SDGLYCKTPKZBGI-DALCUZTNSA-N
Smiles O=C(/N=C(N(C3=CC=C(Cl)C=C3)C2=O)\S/C2=C/C(OC)=O)C1=CC=C(Cl)C=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 4.7 10

Preparing Stock Solutions

The following data is based on the product molecular weight 469.73. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.13 mL 10.64 mL 21.29 mL
5 mM 0.43 mL 2.13 mL 4.26 mL
10 mM 0.21 mL 1.06 mL 2.13 mL
50 mM 0.04 mL 0.21 mL 0.43 mL

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Product Datasheets

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References

References are publications that support the products' biological activity.

Kato et al (1999) In vitro antiplatelet profile of FR171113, a novel non-peptide thrombin receptor antagonist. Eur.J.Pharmacol. 384 197 PMID: 10611442

Kato et al (2003) Inhibition of arterial thrombosis by a protease-activated receptor 1 antagonist, FR171113, in the guinea pig. Eur.J.Pharmacol. 473 163 PMID: 12892834


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Citations for FR 171113

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Literature in this Area

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Pathways for FR 171113

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