FPL 55712

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Cat.No. 2276 - FPL 55712 | C27H30O9 | CAS No. 40785-97-5
Description: Leukotriene receptor antagonist
Chemical Name: 7-[3-(4-Acetyl-3-hydroxy-2-propylphenoxy)-2-hydroxypropoxy]-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid
Purity: ≥97% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Leukotriene receptor antagonist; inhibits contraction of guinea pig trachealis induced by leukotrienes C4, D4, E4 and F4.

Technical Data

M. Wt 498.52
Formula C27H30O9
Storage Store at -20°C
Purity ≥97% (HPLC)
CAS Number 40785-97-5
PubChem ID 105007
InChI Key LMQBMWHHGVZWMR-UHFFFAOYSA-N
Smiles CCCC1=C(O)C(=CC=C1OCC(O)COC1=CC=C2C(=O)C=C(OC2=C1CCC)C(O)=O)C(C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
100mM NaOH 24.93 50

Preparing Stock Solutions

The following data is based on the product molecular weight 498.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.01 mL 10.03 mL 20.06 mL
5 mM 0.4 mL 2.01 mL 4.01 mL
10 mM 0.2 mL 1 mL 2.01 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Jones et al (1983) Pharmacological study of the effects of leukotrienes C4, D4, E4 & F4 on guinea pig trachealis: interaction with FPL-55712. Prostaglandins 26 833 PMID: 6322240

O'Donnell and Welto (1984) Pharmacologic properties of FPL 55712 administered by aerosol. Agents Actions 14 43 PMID: 6322547

Folkerts et al (1995) Leukotrienes mediate tracheal hyperresponsiveness after nitric oxide synthesis inhibition. Eur.J.Pharmacol. 285 R1 PMID: 8566126


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Keywords: leukotrienes eicosanoids receptor antagonists CysLT1 Receptors receptors LTD4 LTE4 FPL55712 Leukotriene and Related Receptors

Citations for FPL 55712

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Pathways for FPL 55712

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