FPL 55712
Biological Activity
Leukotriene receptor antagonist; inhibits contraction of guinea pig trachealis induced by leukotrienes C4, D4, E4 and F4.
Technical Data
| M. Wt | 498.52 |
| Formula | C27H30O9 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 40785-97-5 |
| PubChem ID | 105007 |
| InChI Key | LMQBMWHHGVZWMR-UHFFFAOYSA-N |
| Smiles | CCCC1=C(O)C(=CC=C1OCC(O)COC1=CC=C2C(=O)C=C(OC2=C1CCC)C(O)=O)C(C)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 100mM NaOH | 24.93 | 50 |
Preparing Stock Solutions
The following data is based on the product molecular weight 498.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.01 mL | 10.03 mL | 20.06 mL |
| 5 mM | 0.4 mL | 2.01 mL | 4.01 mL |
| 10 mM | 0.2 mL | 1 mL | 2.01 mL |
| 50 mM | 0.04 mL | 0.2 mL | 0.4 mL |
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Product Datasheets
References
References are publications that support the products' biological activity.
Jones et al (1983) Pharmacological study of the effects of leukotrienes C4, D4, E4 & F4 on guinea pig trachealis: interaction with FPL-55712. Prostaglandins 26 833 PMID: 6322240
O'Donnell and Welto (1984) Pharmacologic properties of FPL 55712 administered by aerosol. Agents Actions 14 43 PMID: 6322547
Folkerts et al (1995) Leukotrienes mediate tracheal hyperresponsiveness after nitric oxide synthesis inhibition. Eur.J.Pharmacol. 285 R1 PMID: 8566126
If you know of a relevant reference for FPL 55712, please let us know.
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Keywords: leukotrienes eicosanoids receptor antagonists CysLT1 Receptors receptors LTD4 LTE4 FPL55712 Leukotriene and Related Receptors
Citations for FPL 55712
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