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Leukotriene receptor antagonist; inhibits contraction of guinea pig trachealis induced by leukotrienes C4, D4, E4 and F4.
|Storage||Store at -20°C|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions
The following data is based on the product molecular weight 498.52. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|0.5 mM||4.01 mL||20.06 mL||40.12 mL|
|2.5 mM||0.8 mL||4.01 mL||8.02 mL|
|5 mM||0.4 mL||2.01 mL||4.01 mL|
|25 mM||0.08 mL||0.4 mL||0.8 mL|
References are publications that support the biological activity of the product.
Jones et al (1983) Pharmacological study of the effects of leukotrienes C4, D4, E4 & F4 on guinea pig trachealis: interaction with FPL-55712. Prostaglandins 26 833 PMID: 6322240
O'Donnell and Welto (1984) Pharmacologic properties of FPL 55712 administered by aerosol. Agents Actions 14 43 PMID: 6322547
Folkerts et al (1995) Leukotrienes mediate tracheal hyperresponsiveness after nitric oxide synthesis inhibition. Eur.J.Pharmacol. 285 R1 PMID: 8566126
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Keywords: FPL 55712, FPL 55712 supplier, leukotrienes, eicosanoids, receptor, antagonists, CysLT1, Receptors, receptors, LTD4, LTE4, FPL55712, Leukotriene, and, Related, 2276, Tocris Bioscience
1 Citation for FPL 55712
Citations are publications that use Tocris products. Selected citations for FPL 55712 include:
Wright et al (2019) Pranlukast is a novel small molecule activator of the two-pore domain potassium channel TREK2. Biochem Biophys Res Commun 520 35 PMID: 31564414
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