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Description: Potent CDK14 and CDK16 inhibitor; displays reversible inhibition of CDK14
Chemical Name: N-(1-((3-(4-(Dimethylamino)butanamido)phenyl)sulfonyl)piperidin-4-yl)-4-(2,4,6-trichlorobenzamido)-1H-pyrazole-3-carboxamide
Purity: ≥98% (HPLC)

Biological Activity for FMF-04-159-R

FMF-04-159-R is a potent inhibitor of CDK16 and CDK14 (IC50 values are 6 and 140 nM, respectively in kinase activity assay; IC50 = 563 nM for CDK14 in BRET assay). Also binds CDK2 (IC50 = 493 nM). Inhibition reversible upon compound wash-out. Control for FMF-04-159-2 (Cat. No. 7158).

Technical Data for FMF-04-159-R

M. Wt 685.02
Formula C28H32Cl3N7O5S
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 2741262-15-5
Smiles CN(CCCC(NC1=CC=CC(S(=O)(N2CCC(NC(C3=NNC=C3NC(C4=C(C=C(C=C4Cl)Cl)Cl)=O)=O)CC2)=O)=C1)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for FMF-04-159-R

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 68.5 100
ethanol 34.25 50

Preparing Stock Solutions for FMF-04-159-R

The following data is based on the product molecular weight 685.02. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.46 mL 7.3 mL 14.6 mL
5 mM 0.29 mL 1.46 mL 2.92 mL
10 mM 0.15 mL 0.73 mL 1.46 mL
50 mM 0.03 mL 0.15 mL 0.29 mL

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References for FMF-04-159-R

References are publications that support the biological activity of the product.

Ferguson et al (2019) Discovery of covalent CDK14 inhibitors with pan-TAIRE family specificity. Cell Chem.Biol. 26 804 PMID: 30930164

If you know of a relevant reference for FMF-04-159-R, please let us know.

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Keywords: FMF-04-159-R, FMF-04-159-R supplier, cyclin, dependent, kinase, Cdk, CDK, inhibitors, inhibits, CDK14, CDK16, CDK2, CDK17, CDK18, TAIRE, family, kinases, reversible, CDK5, Subfamily, 7159, Tocris Bioscience

Citations for FMF-04-159-R

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