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Cat.No. 3293 - Finasteride | C23H36N2O2 | CAS No. 98319-26-7
Description: Type II 5α-reductase inhibitor
Alternative Names: MK 906
Chemical Name: (5α,17β)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
Purity: ≥99% (HPLC)
Citations (2)

Biological Activity

Antiandrogen that inhibits type II 5α reductase (IC50 = 65 nM). Suppresses the conversion of testosterone to dihydrotestosterone. Reduces prostatic dihydrotestosterone levels and prostate size in vivo. Orally active.

Technical Data

M. Wt 372.54
Formula C23H36N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 98319-26-7
PubChem ID 57363
Smiles C[C@@]34[C@](CC[C@@H]4[C@@](NC(C)(C)C)=O)([H])[C@]2([H])CC[C@@]1([H])NC(C=C[C@@](C)1[C@]([H])2CC3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 37.25 100
ethanol 37.25 100

Preparing Stock Solutions

The following data is based on the product molecular weight 372.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.42 mL 26.84 mL
5 mM 0.54 mL 2.68 mL 5.37 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Keywords: Finasteride, Finasteride supplier, Type, II, 5α-reductases, 5alpha-reductases, inhibitors, inhibits, MK906, MK, 906, Other, Reductase, Androgen, Receptor, 3293, Tocris Bioscience

2 Citations for Finasteride

Citations are publications that use Tocris products. Selected citations for Finasteride include:

Ferando and Mody (2013) Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits 7 144 PMID: 24062647

Handa et al (2013) Central 5-α reduction of testost. is required for testosterone's inhibition of the hypothalamo-pituitary-adrenal axis response to restraint stress in adult male rats. Nat Neurosci 1529 74 PMID: 23880372

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