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Biological Activity for Finasteride
Finasteride is an antiandrogen that inhibits type II 5α reductase (IC50 = 65 nM). Suppresses the conversion of testosterone to dihydrotestosterone. Reduces prostatic dihydrotestosterone levels and prostate size in vivo. Orally active.
Technical Data for Finasteride
|Storage||Store at RT|
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Finasteride
|Solvent||Max Conc. mg/mL||Max Conc. mM|
Preparing Stock Solutions for Finasteride
The following data is based on the product molecular weight 372.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||2.68 mL||13.42 mL||26.84 mL|
|5 mM||0.54 mL||2.68 mL||5.37 mL|
|10 mM||0.27 mL||1.34 mL||2.68 mL|
|50 mM||0.05 mL||0.27 mL||0.54 mL|
References for Finasteride
References are publications that support the biological activity of the product.
Thigpen and Russell (1992) Four-amino acid segment in steroid 5α-reductase 1 confers sensitivity to finasteride, a competitive inhibitor. J.Biol.Chem. 267 8577 PMID: 1314830
Gao et al (2004) Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5α-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. Endocrinology 145 5420 PMID: 15308613
Mukai et al (2008) Studies on neurosteroids XXV. Influence of a 5α-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism. Biol.Pharm.Bull. 31 1646 PMID: 18758053
If you know of a relevant reference for Finasteride, please let us know.
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Keywords: Finasteride, Finasteride supplier, Type, II, 5α-reductases, 5alpha-reductases, inhibitors, inhibits, MK906, MK, 906, Other, Reductase, Androgen, Receptor, 3293, Tocris Bioscience
2 Citations for Finasteride
Citations are publications that use Tocris products. Selected citations for Finasteride include:
Ferando and Mody (2013) Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits 7 144 PMID: 24062647
Handa et al (2013) Central 5-α reduction of testost. is required for testosterone's inhibition of the hypothalamo-pituitary-adrenal axis response to restraint stress in adult male rats. Nat Neurosci 1529 74 PMID: 23880372
Do you know of a great paper that uses Finasteride from Tocris? Please let us know.
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