Finasteride

Pricing Availability Delivery Time Qty
Cat.No. 3293 - Finasteride | C23H36N2O2 | CAS No. 98319-26-7
Description: Type II 5α-reductase inhibitor
Alternative Names: MK 906
Chemical Name: (5α,17β)-N-(1,1-Dimethylethyl)-3-oxo-4-azaandrost-1-ene-17-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (2)
Literature

Biological Activity

Antiandrogen that inhibits type II 5α reductase (IC50 = 65 nM). Suppresses the conversion of testosterone to dihydrotestosterone. Reduces prostatic dihydrotestosterone levels and prostate size in vivo. Orally active.

Technical Data

M. Wt 372.54
Formula C23H36N2O2
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 98319-26-7
PubChem ID 57363
InChI Key DBEPLOCGEIEOCV-WSBQPABSSA-N
Smiles C[C@@]34[C@](CC[C@@H]4[C@@](NC(C)(C)C)=O)([H])[C@]2([H])CC[C@@]1([H])NC(C=C[C@@](C)1[C@]([H])2CC3)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 37.25 100
ethanol 37.25 100

Preparing Stock Solutions

The following data is based on the product molecular weight 372.54. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.68 mL 13.42 mL 26.84 mL
5 mM 0.54 mL 2.68 mL 5.37 mL
10 mM 0.27 mL 1.34 mL 2.68 mL
50 mM 0.05 mL 0.27 mL 0.54 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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Safety Datasheet

References

References are publications that support the products' biological activity.

Thigpen and Russell (1992) Four-amino acid segment in steroid 5α-reductase 1 confers sensitivity to finasteride, a competitive inhibitor. J.Biol.Chem. 267 8577 PMID: 1314830

Gao et al (2004) Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5α-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats: new approach for benign prostate hyperplasia. Endocrinology 145 5420 PMID: 15308613

Mukai et al (2008) Studies on neurosteroids XXV. Influence of a 5α-reductase inhibitor, finasteride, on rat brain neurosteroid levels and metabolism. Biol.Pharm.Bull. 31 1646 PMID: 18758053


If you know of a relevant reference for Finasteride, please let us know.

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Keywords: Type II 5α-reductases 5alpha-reductases inhibitors inhibits MK906 MK 906 Other Reductase

2 Citations for Finasteride

Citations are publications that use Tocris products. Selected citations for Finasteride include:

Ferando and Mody (2013) Altered gamma oscillations during pregnancy through loss of δ subunit-containing GABA(A) receptors on parvalbumin interneurons. Front Neural Circuits 7 144 PMID: 24062647

Handa et al (2013) Central 5-α reduction of testosterone is required for testosterone's inhibition of the hypothalamo-pituitary-adrenal axis response to restraint stress in adult male rats. Nat Neurosci 1529 74 PMID: 23880372


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New Product Guide (Spring/Summer 2017)

Our new product guide highlights over 130 new products added to the Tocris Bioscience range during the first half of 2017.

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Pathways for Finasteride

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