FERb 033

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Cat.No. 3523 - FERb 033 | C13H9ClFNO3 | CAS No. 1111084-78-6
Description: Potent and selective ERβ agonist
Chemical Name: 2-Chloro-3'-fluoro-3,4'-dihydroxy-[1,1-biphenyl]-4-carboxaldehyde oxime
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature
Pathways

Biological Activity

Potent and selective ERβ receptor agonist (Ki = 7.1 nM, EC50 = 4.8 nM). Displays 62-fold selectivity over ERα.

Compound Libraries

FERb 033 is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 281.67
Formula C13H9ClFNO3
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 1111084-78-6
PubChem ID 74429219
InChI Key IEBJACOMZQEPOY-UHFFFAOYSA-N
Smiles OC1=C(/C=N/O)C=CC(C2=CC=C(O)C(F)=C2)=C1Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.17 100
ethanol 28.17 100

Preparing Stock Solutions

The following data is based on the product molecular weight 281.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.55 mL 17.75 mL 35.5 mL
5 mM 0.71 mL 3.55 mL 7.1 mL
10 mM 0.36 mL 1.78 mL 3.55 mL
50 mM 0.07 mL 0.36 mL 0.71 mL

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References

References are publications that support the biological activity of the product.

Minutolo et al (2009) Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor β. J.Med.Chem. 52 858 PMID: 19128016


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Citations for FERb 033

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Literature in this Area

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Pathways for FERb 033

Estrogen

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.