Felbamate

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Cat.No. 0869 - Felbamate | C11H14N2O4 | CAS No. 25451-15-4
Description: NMDA antagonist; acts glycine site
Chemical Name: 2-Phenyl-1,3-propanedioldicarbamate
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (11)

Biological Activity

Anticonvulsant, acting as an antagonist at the NMDA-associated glycine binding site.

Compound Libraries

Felbamate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data

M. Wt 238.24
Formula C11H14N2O4
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 25451-15-4
PubChem ID 3331
InChI Key WKGXYQFOCVYPAC-UHFFFAOYSA-N
Smiles NC(=O)OCC(COC(N)=O)C1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 23.82 100
ethanol 23.82 100

Preparing Stock Solutions

The following data is based on the product molecular weight 238.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 4.2 mL 20.99 mL 41.97 mL
5 mM 0.84 mL 4.2 mL 8.39 mL
10 mM 0.42 mL 2.1 mL 4.2 mL
50 mM 0.08 mL 0.42 mL 0.84 mL

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Product Datasheets

Certificate of Analysis / Product Datasheet
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References

References are publications that support the biological activity of the product.

Coffin et al (1994) Selective antagonism of the anticonvulsant effects of felb. by glycine. Eur.J.Pharmacol. 256 R9 PMID: 8050461

De Sarro et al (1994) Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felb. in DBA/2 mice. Eur.J.Pharmacol. 262 11 PMID: 7529182

Serra et al (1994) Felbamate antagonises isoniazid- and FG7142-induced reduction of GABAA receptor function in the mouse brain. Eur.J.Pharmacol. 265 185 PMID: 7875235

Upton (1994) Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. TiPS 15 456 PMID: 7886818


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Keywords: Felbamate, Felbamate supplier, NMDA, antagonist, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 0869, Tocris Bioscience

Citations for Felbamate

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* or download your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


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