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Submit ReviewFelbamate
Description: NMDA antagonist; acts glycine site
Chemical Name: 2-Phenyl-1,3-propanedioldicarbamate
Purity: ≥99% (HPLC)
Biological Activity
Anticonvulsant, acting as an antagonist at the NMDA-associated glycine binding site.
Compound Libraries
Felbamate is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data
| M. Wt | 238.24 |
| Formula | C11H14N2O4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 25451-15-4 |
| PubChem ID | 3331 |
| InChI Key | WKGXYQFOCVYPAC-UHFFFAOYSA-N |
| Smiles | NC(=O)OCC(COC(N)=O)C1=CC=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 23.82 | 100 | |
| ethanol | 23.82 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 238.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 4.2 mL | 20.99 mL | 41.97 mL |
| 5 mM | 0.84 mL | 4.2 mL | 8.39 mL |
| 10 mM | 0.42 mL | 2.1 mL | 4.2 mL |
| 50 mM | 0.08 mL | 0.42 mL | 0.84 mL |
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References
References are publications that support the biological activity of the product.
Coffin et al (1994) Selective antagonism of the anticonvulsant effects of felb. by glycine. Eur.J.Pharmacol. 256 R9 PMID: 8050461
De Sarro et al (1994) Excitatory amino acid neurotransmission through both NMDA and non-NMDA receptors is involved in the anticonvulsant activity of felb. in DBA/2 mice. Eur.J.Pharmacol. 262 11 PMID: 7529182
Serra et al (1994) Felbamate antagonises isoniazid- and FG7142-induced reduction of GABAA receptor function in the mouse brain. Eur.J.Pharmacol. 265 185 PMID: 7875235
Upton (1994) Mechanisms of action of new antiepileptic drugs: rational design and serendipitous findings. TiPS 15 456 PMID: 7886818
If you know of a relevant reference for Felbamate, please let us know.
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Keywords: Felbamate, Felbamate supplier, NMDA, antagonist, glycine, site, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, 0869, Tocris Bioscience
Citations for Felbamate
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Currently there are no citations for Felbamate. Do you know of a great paper that uses Felbamate from Tocris? Please let us know.
Reviews for Felbamate
Average Rating: 5 (Based on 1 Review.)
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Block of NMDA receptor glycine site.
By
Sergiy Sylantyev on 10/15/2020
Species: Human
Cell Line/Tissue: Stem cell - derived neurons
Felbamate was in use as an NMDA receptor antagonist affecting glycine site, to study (possible) competition of dopamine for this site. Application of felbamate and dopamine mixtures in different ratios resulted in a significant decrease of single-channel NMDA receptor openings recorded from outside-out neuron membrane patches. No problem with dissolution in DMSO. Illustration: the effect of 75% dopamine EC50 + 25% Felbamate EC50 on NMDA receptor single-channel openings (top trace); then 50%/50% and 25%/75% ratios.
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