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Cat.No. 3588 - Estropipate | C18H22O5S.C4H10N2 | CAS No. 7280-37-7
Description: Estrogen receptor agonist and OATP1B1 inhibitor
Chemical Name: Piperazine estrone sulfate
Purity: ≥97% (HPLC)
Literature (2)
Pathways (1)

Biological Activity

Estrogen receptor agonist. Also inhibits organic anion transporting polypeptide 1B1 (OATP1B1) (IC50= 70 nM).

Technical Data

M. Wt 436.56
Formula C18H22O5S.C4H10N2
Storage Store at RT
Purity ≥97% (HPLC)
CAS Number 7280-37-7
PubChem ID 5284555
Smiles O=C4CC[C@@]3([H])[C@]2([H])CCC1=CC(OS(=O)(O)=O)=CC=C1[C@]([H])2CC[C@@]34C.C5NCCNC5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
water 2.18 5
DMSO 43.66 100

Preparing Stock Solutions

The following data is based on the product molecular weight 436.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.29 mL 11.45 mL 22.91 mL
5 mM 0.46 mL 2.29 mL 4.58 mL
10 mM 0.23 mL 1.15 mL 2.29 mL
50 mM 0.05 mL 0.23 mL 0.46 mL

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References are publications that support the biological activity of the product.

Williams et al (2004) Estrogen regulation of the cytochrome P450 3A subfamily in humans. J.Pharmacol.Exp.Ther. 311 728 PMID: 15282264

Obaidat et al (2009) A cell-based high-throughput assay to identify inhibitors of organic anion transporting polypeptides 1B1 and 1B3. FASEB J. 23 748

If you know of a relevant reference for Estropipate, please let us know.

View Related Products by Product Action

View all Estrogen and Related Receptor Agonists

Keywords: Estropipate, Estropipate supplier, Estrogen, receptor, agonists, OATP1B, inhibitors, inhibits, and, Related, Receptors, Multidrug, Transporters, 3588, Tocris Bioscience

⚠ WARNING: This product can expose you to chemicals including Estropipate, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to

Citations for Estropipate

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Literature in this Area

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Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Nuclear Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors

Pathways for Estropipate


Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.