ES 936

Discontinued Product

ES 936 (Cat. No. 4022) has been withdrawn from sale for commercial reasons.
Cat.No. 4022 - ES 936 | C18H16N2O6 | CAS No. 192820-78-3
Description: Mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase (NQO1)
Chemical Name: 5-Methoxy-1,2-dimethyl-3-[(4-nitrophenyoxy)methyl]-1H-indole
Purity: ≥98% (HPLC)
Literature (1)

Biological Activity

Mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase (NQO1). Induces growth inhibition in human pancreatic carcinoma (MIA PaCa-2) and adenocarcinoma (BxPC-3) cell lines with IC50 values of 108 and 365 nM respectively. Also inhibits TNF-α-induced E-selectin protein expression in human bone marrow endothelial cells. Exhibits no effects on other cellular reductases or levels of acid-soluble thiols.

Technical Data

M. Wt 356.33
Formula C18H16N2O6
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 192820-78-3
Smiles O=C(C=C1OC)C2=C(C(COC3=CC=C([N+]([O-])=O)C=C3)=C(C)N2C)C1=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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Keywords: ES 936, ES 936 supplier, ES936, mechanism-based, inhibitor, NADPH, quinone, oxidoreductase, NQO1, inhibitors, inhibits, NADH, Other, Reductase, 4022, Tocris Bioscience

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