ER 819762

Pricing Availability Delivery Time Qty
Cat.No. 5924 - ER 819762 | C30H39N3O3 | CAS No. 1155773-15-1
Description: Potent EP4 receptor antagonist; orally bioavailable
Chemical Name: (10S)-1'-[(3,5-Dimethylphenyl)methyl]-2-ethyl-5,10-dihydro-7,9-dimethoxy-10-methylspiro[1H-imidazo[1,5-b][2]benzazepine-1,4'-piperidin]-3(2H)-one
Purity: ≥98% (HPLC)
Datasheet
Citations
Literature

Biological Activity

Potent EP4 receptor antagonist (IC50 = 59 nM). Suppresses EP4-mediated Th1 differentiation, Th17 cell expansion, and IL-23 secretion by activated dendritic cells. Inhibits Th1 and Th17 cytokine production, suppresses collagen- and GPI-induced arthritis in mice. Attenuates CFA-induced inflammatory pain in rats. Analgesic. Orally bioavailable.

Technical Data

M. Wt 489.65
Formula C30H39N3O3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1155773-15-1
PubChem ID 42596951
InChI Key ANKFBAJRCGOKJJ-QFIPXVFZSA-N
Smiles CCN1C(N2CC3=CC(OC)=CC(OC)=C3[C@H](C=C2C14CCN(CC4)CC5=CC(C)=CC(C)=C5)C)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

All Tocris products are intended for laboratory research use only.

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 0.98 2mM with gentle warming
ethanol 2.45 5mM with gentle warming

Preparing Stock Solutions

The following data is based on the product molecular weight 489.65. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.04 mL 10.21 mL 20.42 mL
5 mM 0.41 mL 2.04 mL 4.08 mL
10 mM 0.2 mL 1.02 mL 2.04 mL
50 mM 0.04 mL 0.2 mL 0.41 mL

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Product Datasheets

Safety Datasheet

References

References are publications that support the products' biological activity.

Chen et al (2010) A novel antagonist of the prostaglandin E2 EP4 receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models. Br.J.Pharmacol. 160 292 PMID: 20423341

Jones et al (2016) Role of EP2 and EP4 receptors in airway microvascular leak induced by prostaglandin E2. Br.J.Pharmacol. 173 992 PMID: 26639895


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