Pricing Availability   Qty
Description: Potent COMT inhibitor; blocks α-synuclein aggregation
Chemical Name: (2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide
Purity: ≥99% (HPLC)
Literature (1)

Biological Activity for Entacapone

Entacapone is a potent catechol O-methyltransferase (COMT) inhibitor (IC50 values are 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and membrane-bound COMT respectively). Increases bioavailability of levodopa when given as an adjunct therapy for Parkinson's disease. Inhibits α-synuclein aggregation in an in vitro assay; blocks α-synuclein-induced cell death in PC-12 cells.

Technical Data for Entacapone

M. Wt 305.29
Formula C14H15N3O5
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 130929-57-6
PubChem ID 5281081
Smiles OC1=CC(/C=C(C#N)/C(N(CC)CC)=O)=CC([N+]([O-])=O)=C1O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Entacapone

Solvent Max Conc. mg/mL Max Conc. mM
DMSO 30.53 100
ethanol 3.05 10

Preparing Stock Solutions for Entacapone

The following data is based on the product molecular weight 305.29. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.28 mL 16.38 mL 32.76 mL
5 mM 0.66 mL 3.28 mL 6.55 mL
10 mM 0.33 mL 1.64 mL 3.28 mL
50 mM 0.07 mL 0.33 mL 0.66 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.


Dilution Calculator

Calculate the dilution required to prepare a stock solution.

References for Entacapone

References are publications that support the biological activity of the product.

Di Giovanni et al (2010) Entacapone and tolcapone, two catechol O-methyltransferase inhibitors, block fibril formation of alpha-synuclein and beta-amyloid and protect against amyloid-induced toxicity. J.Biol.Chem. 285 14941 PMID: 20150427

Forsberg et al (2003) Pharmacokinetics and pharmacodynamics of entac. and tolc. after acute and repeated administration: a comparative study in the rat. J.Pharmacol.Exp.Ther. 304 498 PMID: 12538800

Merello et al (1994) Effect of entacapone, a peripherally acting catechol-O-methyltransferase inhibitor, on the motor response to acute treatment with lev. in patients with Parkinson's disease. J.Neurol.Neurosurg.Psychiatry 57 186 PMID: 8126502

If you know of a relevant reference for Entacapone, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Catechol O-Methyltransferase Inhibitors

Keywords: Entacapone, Entacapone supplier, potent, catechol, O, methyltransferase, COMT, inhibitors, inhibits, Parkinsons, disease, alpha, synuclein, a-syn, aggregation, 3-O-methyldopa, parkinson's, Catechol, O-Methyltransferase, 4720, Tocris Bioscience

Citations for Entacapone

Citations are publications that use Tocris products.

Currently there are no citations for Entacapone. Do you know of a great paper that uses Entacapone from Tocris? Please let us know.

Reviews for Entacapone

There are currently no reviews for this product. Be the first to review Entacapone and earn rewards!

Have you used Entacapone?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.

Parkinson's Disease Poster

Parkinson's Disease Poster

Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.